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AB121758

Anti-EFCAB1 antibody

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(1 Publication)

Rabbit Polyclonal EFCAB1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CLXN aa 100 to C-terminus.

View Alternative Names

EFCAB1, ODAD5, CLXN, Calaxin, EF-hand calcium-binding domain-containing protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EFCAB1 antibody (AB121758)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EFCAB1 antibody (AB121758)

ab1211758 at 1/15 dilution staining EFCAB1 in Paraffin-embedded Human duodenum tissue by Immunohistochemistry.

Western blot - Anti-EFCAB1 antibody (AB121758)
  • WB

Unknown

Western blot - Anti-EFCAB1 antibody (AB121758)

All lanes:

Western blot - Anti-EFCAB1 antibody (ab121758) at 1/250 dilution

Lane 1:

vector only transfected HEK293T lysate

Lane 2:

EFCAB1-transfected HEK293T lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa))

Predicted band size: 24 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human CLXN aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9HAE3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/20", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EFCAB1 also known as EF-hand calcium-binding domain-containing protein 1 has an approximate mass of 32 kDa. This protein functions by interacting with calcium ions through its EF-hand domains which allows it to play a role in calcium signaling. EFCAB1 expression occurs in the testes and various other tissues indicating its relevance in multiple biological processes. Its calcium-binding capability suggests its involvement in processes where calcium acts as a secondary messenger.
Biological function summary

The activities linked with EFCAB1 influence cellular signaling and regulation. It may associate with other cellular components to form complexes that adjust calcium dynamics therefore participating in signaling pathways that depend on calcium fluctuations. In doing so EFCAB1 aids in modulating activities that range from muscle contraction to neurotransmitter release exhibiting its versatility across physiological systems.

Pathways

EFCAB1 may influence important biological pathways like calcium signaling and possibly the MAPK signaling pathway. Through such pathways EFCAB1 works alongside other proteins such as calmodulin and kinases to facilitate proper cellular responses to external stimuli. These interactions highlight EFCAB1’s contribution to maintaining cellular homeostasis and function through complex signaling cascades.

Altered function of EFCAB1 may connect to conditions such as idiopathic male infertility and certain types of cancers. The relationship between EFCAB1 and these disorders may be due to its role in calcium signaling as proper calcium homeostasis is critical for processes like spermatogenesis and cell proliferation. Proteins such as the protein kinase C family could link with EFCAB1 in these pathological contexts suggesting common pathways may contribute to disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (By similarity).
See full target information CLXN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Open biology 14:240075 PubMed39043225

2024

A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction.

Applications

Unspecified application

Species

Unspecified reactive species

Lorraine Glennie,Marta Codina Solà,Mar Xunclà,Gloria Aparicio Español,Elena Garcia-Arumí,Eduardo Fidel Tizzano,Nicola T Wood,Thomas J Macartney,Amaia Lasa-Aranzasti,Gopal P Sapkota
View all publications
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Product promise

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