Rabbit Polyclonal EFHD1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human EFHD1 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human EFHD1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BUP0
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899). May play a role in neuronal differentiation (By similarity).
Alternative names
SWS2, PP3051, EFHD1, EF-hand domain-containing protein D1, EF-hand domain-containing protein 1, Swiprosin-2
Recommended products
Rabbit Polyclonal EFHD1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human EFHD1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human EFHD1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BUP0
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
EFHD1 also known as EF-hand domain family member D1 is a protein encoded by the EFHD1 gene. This protein weighs approximately 25 kDa and is involved in calcium-binding due to its EF-hand domains. EFHD1 is expressed in various tissues including the skeletal muscles and brain. Its expression in these tissues suggests potential roles in muscle function and neurological processes.
- Biological function summary
EFHD1 participates in the regulation of cellular processes through calcium signaling. It acts as a modulator adjusting cellular responses to alterations in calcium levels. While not a component of a larger protein complex EFHD1 interacts with other calcium-binding proteins which may enhance its regulatory functions in cellular activities.
- Pathways
Calcium-binding properties of EFHD1 enable it to interact with signal transduction and apoptosis pathways. Its involvement in calcium-mediated signal transduction helps in the transmission of messages within cells which affects cell function and survival. EFHD1 may interact with proteins such as calmodulin indicating a role in the modulation of calcium-dependent signaling events.
- Associated diseases and disorders
EFHD1 has connections to neurodegenerative diseases such as Alzheimer's disease. Its role in calcium regulation links it to the dysfunction observed in these disorders where calcium imbalance leads to cellular damage. EFHD1 also associates with proteins like tau which are implicated in Alzheimer's pathology hinting at potential pathways for disease modulation or therapeutic targeting.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EFHD1 antibody (ab118599)
ab118599, at 5 µg/ml, staining EFHD1 in formalin fixed, paraffin embedded Human adrenal tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EFHD1 antibody (ab118599)
ab118599, at 5 µg/ml, staining EFHD1 in formalin fixed, paraffin embedded Human lung tissue by Immunohistochemistry.
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