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AB24368

Anti-EFHD2/SWS1 antibody

4

(1 Review)

|

(6 Publications)

Goat Polyclonal EFHD2/SWS1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human EFHD2 aa 200 to C-terminus.

View Alternative Names

SWS1, EFHD2, EF-hand domain-containing protein D2, Swiprosin-1

1 Images
Western blot - Anti-EFHD2/SWS1 antibody (AB24368)
  • WB

Supplier Data

Western blot - Anti-EFHD2/SWS1 antibody (AB24368)

Western blot analysis labeling EFHD2/SWS1 with ab24368 at 0.5 ug/ml.

All lanes:

Western blot - Anti-EFHD2/SWS1 antibody (ab24368) at 0.5 µg/mL

Lane 1:

Human thymus lysate at 35 µg

Lane 2:

Human lymph node lysate at 35 µg

Lane 3:

Human tonsil lysate at 35 µg

Predicted band size: 26 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human EFHD2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96C19

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EFHD2 also known as SWS1 is a calcium-binding protein with a mass of approximately 25 kilodaltons. It has an EF-hand motif that facilitates interaction with calcium ions playing a role in actin cytoskeleton dynamics. EFHD2 expresses in several tissues particularly in the brain immune cells and certain cancer cell lines. Its presence in these tissues suggests diverse roles ranging from neurotransmission to immune response modulation.
Biological function summary

This protein participates in cell communication and signaling. It serves an important function in various cellular processes and is a component of the neuronal signalosome complex. EFHD2 interacts with actin filaments and influences cell morphology and migration especially in neurons. It also modulates neuronal plasticity affecting learning and memory processes by impacting synaptic activity and stability.

Pathways

The protein EFHD2 is involved in the calcium signaling pathway which is important for cellular responses and adaptations to external signals. It connects with proteins like CAMKII and calcineurin in this pathway modulating their activity. EFHD2 also participates in the immune signaling cascade partnering with proteins such as SLP-76 and VAV to regulate immune cell activation and function.

EFHD2 has links to neurodegenerative diseases like Alzheimer's and immune-related conditions such as rheumatoid arthritis. In Alzheimer's disease modifications in EFHD2 influence tau protein dynamics contributing to neurofibrillary tangle formation. The protein's dysregulation in rheumatoid arthritis affects NF-kB signaling altering the inflammation response. Overall EFHD2's activity and interactions with other proteins are significant in understanding these disorders' pathophysiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
See full target information EFHD2
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 58:102427 PubMed40480147

2025

tsRNA-08614 inhibits glycolysis and histone lactylation by ALDH1A3 to confer oxaliplatin sensitivity in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengbo Chen,Yiyang Zhang,Fang Yan,Gang Zhao,Yan Wang

Nature communications 15:1282 PubMed38346956

2024

EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.

Applications

Unspecified application

Species

Unspecified reactive species

Jiacheng Wu,Xiaoqing Xu,Jiaqi Duan,Yangyang Chai,Jiaying Song,Dongsheng Gong,Bingjing Wang,Ye Hu,Taotao Han,Yuanyuan Ding,Yin Liu,Jingnan Li,Xuetao Cao

Frontiers in pharmacology 13:876469 PubMed35517816

2022

Anti-Apoptosis of Podocytes and Pro-Apoptosis of Mesangial Cells for Telmisartan in Alleviating Diabetic Kidney Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wei,Yabin Ma,Ya Li,Wenzhao Zhang,Yuting Zhong,Yue Yu,Li-Chao Zhang,Zhibin Wang,Ye Tu

American journal of translational research 13:210-222 PubMed33527019

2021

Schisandrin C attenuates renal damage in diabetic nephropathy by regulating macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Wang,Jingqiu Cui,Ming Liu,Yingqi Shao,Xiaoying Dong

JCI insight 3: PubMed29415882

2018

Swiprosin-1 deficiency impairs macrophage immune response of septic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Su Zhang,Ye Tu,Yi-Ming Sun,Ya Li,Rong-Mei Wang,Yongbing Cao,Ling Li,Li-Chao Zhang,Zhi-Bin Wang

Journal of neuropathology and experimental neurology 73:1166-82 PubMed25383639

2014

The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.

Applications

WB

Species

Unspecified reactive species

Eva Borger,Abigail Herrmann,David A Mann,Tara Spires-Jones,Frank Gunn-Moore
View all publications
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