Rabbit Polyclonal EGFL6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EGFL6 aa 1-250.
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Publications
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- Clinical & experimental metastasis 40:357-3712023EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoting Song,Xu Cheng,Xiangang Jin,Shengyu Ruan,Xianquan Xu,Feng Lu,Xinhui Wu,Fangying Lu,Mingxuan Feng,Liwei Zhang,Renshan Ge,Haixiao Chen,Zhenghua Hong,Dun HongPubMed 37378837
- Theranostics 11:9738-97512021Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKai Chen,Shijie Liao,Yicheng Li,Haibo Jiang,Yun Liu,Chao Wang,Vincent Kuek,Jacob Kenny,Boxiang Li,Qian Huang,Jianxin Hong,Yan Huang,Shek Man Chim,Jennifer Tickner,Nathan J Pavlos,Jinmin Zhao,Qian Liu,An Qin,Jiake XuPubMed 34815781
- Frontiers in oncology 10:14512020Knockout of by CRISPR/Cas9 Mediated Inhibition of Tumor Angiogenesis in Ovarian Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenhui Zhu et. al.PubMed 32983976
- Cell death & disease 11:3452020miR-6086 inhibits ovarian cancer angiogenesis by downregulating the OC2/VEGFA/EGFL6 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBinhua Wu et. al.PubMed 32393810
- The Kaohsiung journal of medical sciences 35:550-5582019HMGB1 promotes bone fracture healing through activation of ERK signaling pathway in a rat tibial fracture model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMing-Qi Chen,Jing-Jie LuanPubMed 31162822
- Molecular carcinogenesis 58:967-9792019EGFL6 promotes cell proliferation in colorectal cancer via regulation of the WNT/β-catenin pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQing-Wei Zhang,Xin-Tian Zhang,Chao-Tao Tang,Xiao-Lu Lin,Zhi-Zheng Ge,Xiao-Bo LiPubMed 30693973
- Cancer medicine 7:6281-62892018Elevated EGFL6 modulates cell metastasis and growth via AKT pathway in nasopharyngeal carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZiyu Zhu et. al.PubMed 30444069
- BMJ open 8:e0213852018Validation of EGFL6 expression as a prognostic marker in patients with lung adenocarcinoma in Taiwan: a retrospective study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChun-Chi Chang,Wen-Wei Sung,Hui-Ting Hsu,Chung-Min Yeh,Chien-Hsun Lee,Ya-Ling Chen,Ta-Chih Liu,Kun-Tu YehPubMed 29934389
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human EGFL6 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IUX8
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Expected |
| Mouse | Predicted | Predicted | Predicted |
| Rat | Predicted | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity).
Alternative names
MAEG, PP648, UNQ281/PRO320, EGFL6, Epidermal growth factor-like protein 6, EGF-like protein 6, MAM and EGF domains-containing gene protein
Recommended products
Rabbit Polyclonal EGFL6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EGFL6 aa 1-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human EGFL6 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IUX8
- Purification technique
- Affinity purification Immunogen
- Reconstitution
- Reconstitute in 200 µL of water
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
EGFL6 also known as Epidermal Growth Factor-Like Protein 6 or MAEG is a secreted protein that plays a role in the regulation of cell growth. It belongs to the epidermal growth factor (EGF) repeat superfamily and has an approximate mass of 70 kDa. EGFL6 is expressed in various tissues with higher expression noted in fetal tissues particularly the lung and kidney as well as in certain adult tissues like the ovary.
- Biological function summary
This protein influences cell proliferation and differentiation. EGFL6 is not a part of a larger protein complex but functions through its interactions with other cellular components. Its activity affects cell behavior which is especially noted during development and tissue regeneration processes. EGFL6 modulates the extracellular environment through binding to receptor tyrosine kinases mediating signaling that promotes cellular motility and survival.
- Pathways
EGFL6 integrates into significant pathways such as the PI3K/AKT and MAPK signaling pathways. Through these pathways it maintains cellular processes related to growth and survival by interacting with proteins like AKT1 and MAPK1. These signaling cascades are fundamental in mediating responses to growth factors and adjusting cell fate decisions.
- Associated diseases and disorders
Aberrant expression of EGFL6 associates with conditions such as cancer specifically ovarian cancer and melanoma. In these contexts EGFL6 interplays with proteins like VEGF contributing to tumor growth and angiogenesis. Its role in disease suggests potential as a therapeutic target for interventions designed to modulate cancer progression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFL6 antibody (ab140079)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded, Human fetal liver tissue labelling EGFL6 with ab140079 at 1/100 dilution.
Western blot - Anti-EGFL6 antibody (ab140079)
All lanes: Western blot - Anti-EGFL6 antibody (ab140079) at 1/1000 dilution
All lanes: Human fetal kidney lysate
Predicted band size: 61 kDa
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