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AB167281

Anti-EGFL6 antibody

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(1 Publication)

Mouse Polyclonal EGFL6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EGFL6.

View Alternative Names

MAEG, PP648, UNQ281/PRO320, EGFL6, Epidermal growth factor-like protein 6, EGF-like protein 6, MAM and EGF domains-containing gene protein

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human EGFL6.

Q8IUX8

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Alternative Products

Primary Antibodies

AB140079

Anti-EGFL6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFL6 antibody (AB140079)

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Complementary Products

Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

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Proteins & Peptides

AB277002

Recombinant Mouse EGFL6 protein (His tag)

SDS-PAGE - Recombinant Mouse EGFL6 protein (His tag) (AB277002)

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Primary Antibodies

AB203676

Anti-tenomodulin antibody

Western blot - Anti-tenomodulin antibody (AB203676)

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Primary Antibodies

AB54460

Anti-Glucose Transporter GLUT2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Glucose Transporter GLUT2 antibody (AB54460)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EGFL6 also known as Epidermal Growth Factor-Like Protein 6 or MAEG is a secreted protein that plays a role in the regulation of cell growth. It belongs to the epidermal growth factor (EGF) repeat superfamily and has an approximate mass of 70 kDa. EGFL6 is expressed in various tissues with higher expression noted in fetal tissues particularly the lung and kidney as well as in certain adult tissues like the ovary.
Biological function summary

This protein influences cell proliferation and differentiation. EGFL6 is not a part of a larger protein complex but functions through its interactions with other cellular components. Its activity affects cell behavior which is especially noted during development and tissue regeneration processes. EGFL6 modulates the extracellular environment through binding to receptor tyrosine kinases mediating signaling that promotes cellular motility and survival.

Pathways

EGFL6 integrates into significant pathways such as the PI3K/AKT and MAPK signaling pathways. Through these pathways it maintains cellular processes related to growth and survival by interacting with proteins like AKT1 and MAPK1. These signaling cascades are fundamental in mediating responses to growth factors and adjusting cell fate decisions.

Aberrant expression of EGFL6 associates with conditions such as cancer specifically ovarian cancer and melanoma. In these contexts EGFL6 interplays with proteins like VEGF contributing to tumor growth and angiogenesis. Its role in disease suggests potential as a therapeutic target for interventions designed to modulate cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity).
See full target information EGFL6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 23:96 PubMed36707804

2023

Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjuan Chai,Chunpeng Pan,Mingyang Zhang,Haizhong Huo,Haiyan Shan,Jugang Wu
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Product promise

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