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AB205193

Anti-EGFL8 antibody

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(1 Publication)

Rabbit Polyclonal EGFL8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EGFL8 aa 50-250.

View Alternative Names

C6orf8, NG3, UNQ8752/PRO29920, EGFL8, Epidermal growth factor-like protein 8, EGF-like protein 8, Vascular endothelial statin-2, VE-statin-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFL8 antibody (AB205193)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFL8 antibody (AB205193)

Immunohistochemical staining of Human colon carcinoma labeling EGFL8 using ab205193 at 1/100 dilution.

Western blot - Anti-EGFL8 antibody (AB205193)
  • WB

Supplier Data

Western blot - Anti-EGFL8 antibody (AB205193)

All lanes:

Western blot - Anti-EGFL8 antibody (ab205193) at 1/1000 dilution

All lanes:

Jurkat cell lysate

Predicted band size: 32 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human EGFL8 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

Q99944

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EGFL8 also known as epidermal growth factor-like protein 8 is a protein encoded by the EGFL8 gene. This protein weighs approximately 57 kDa and is part of the epidermal growth factor (EGF) family characterized by the presence of EGF-like domains. EGFL8 is expressed in various tissues particularly in the central nervous system and developing organs. These domains facilitate the protein's role in cellular signaling as they can bind to receptors and influence cell growth and differentiation.
Biological function summary

EGFL8 interacts with other proteins to modulate diverse processes including neurodevelopment and organogenesis. It plays an important role in cell adhesion proliferation and migration by engaging with cell surface receptors. The protein may also exist in a complex with other extracellular matrix proteins further influencing its function in tissue architecture. Its regulatory function suggests a potential involvement in maintaining cellular environment and responding to growth signals.

Pathways

EGFL8 is significantly involved in signaling cascades that are important for developmental processes. Notably it participates in the MAPK/ERK pathway where it influences cell cycle dynamics and differentiation. This pathway also involves other proteins such as Ras and MEK which convey signals from growth factor receptors to the nucleus. EGFL8 may also have interactions with the Notch signaling pathway which is essential for various developmental processes and cell fate determination.

EGFL8 has implications in the progression of certain neurodevelopmental disorders and cancers. Its altered expression or mutations can affect normal development potentially contributing to conditions such as autism spectrum disorder and brain tumors. The protein may interact with other dysregulated proteins in these diseases including Notch signaling components and EGF receptor pathways further complicating disease mechanisms and clinical outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information EGFL8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Thoracic cancer 14:2665-2677 PubMed37533139

2023

Sevoflurane suppresses the malignant progression of breast cancer via the hsa_circ_0000129/miR-578/EPSTI1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xuehui Zeng,Qingqi Zheng,Lang Wang,Tao Chen,Wenxin Lin,Quanyang Lin
View all publications
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Product promise

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