Anti-EGR3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

EGR3 also known as Early Growth Response 3 is a transcription factor involved in regulating gene expression. The protein weighs around 40 kDa and is expressed across various tissues including the brain thymus and spleen. EGR3 functions by binding to specific DNA sequences modulating the transcription of target genes. As part of the early growth response proteins it has roles in the nervous system and immune response.

Biological function summary

EGR3 influences several cellular processes by modulating gene expression related to cell growth and apoptosis. It's not part of a complex but acts individually to activate or repress target genes. In the nervous system EGR3 contributes to neuronal plasticity and differentiation. In immune systems it aids in the development and function of thymic cells affecting the maturation of T lymphocytes.

Pathways

EGR3 participates in the MAPK signaling pathway and is highly active in the PI3K/AKT pathway. Within these pathways it interacts with other transcription factors and signaling molecules including EGR1 and EGR2 to regulate cell proliferation and survival. These interactions enable EGR3 to play a significant role in cellular responses to external stimuli and stress.

Associated diseases and disorders

EGR3 has connections to schizophrenia and systemic lupus erythematosus (SLE). Altered expression of EGR3 is observed in these conditions suggesting its involvement in their pathophysiology. In schizophrenia EGR3 has links with proteins such as Neuregulin 1 influencing synaptic plasticity and cognitive functions. Similarly in SLE it interacts with immune response pathways suggesting its role in autoimmunity and inflammation processes.