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AB198197

Anti-EGR4 antibody

3

(1 Review)

|

(4 Publications)

Rabbit Polyclonal EGR4 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human Early growth response protein 4.

View Alternative Names

Early growth response protein 4, EGR-4, AT133, EGR4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGR4 antibody (AB198197)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGR4 antibody (AB198197)

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling EGR4 with ab198197 at a 1/25 dilution.

Western blot - Anti-EGR4 antibody (AB198197)
  • WB

Supplier Data

Western blot - Anti-EGR4 antibody (AB198197)

8% SDS-PAGE

All lanes:

Western blot - Anti-EGR4 antibody (ab198197) at 1/400 dilution

All lanes:

Human fetal brain tissue lysate at 40 µg

Predicted band size: 51 kDa

false

Exposure time: 35s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Early growth response protein 4. The exact immunogen used to generate this antibody is proprietary information.

Q05215

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

{EGR4} also known as Early Growth Response 4 is a transcription factor involved in the regulation of gene expression. It belongs to the EGR family of C2H2-type zinc-finger proteins. EGR4 has a mass of approximately 59 kDa and expresses in a variety of tissues including the brain testis and other nervous tissues. The protein serves as an important regulator in neuronal differentiation and development playing a role in synaptic plasticity and cognitive functions.
Biological function summary

The Early Growth Response 4 protein modulates the transcription of genes involved in cellular growth and apoptosis. It does not work in large complexes but often collaborates with other transcription factors and cofactors. This interaction helps control the expression of genes necessary for cell proliferation differentiation and stress response. EGR4’s activity significantly affects the balance between cell survival and death impacting cellular homeostasis and adaptation to external signals.

Pathways

EGR4 interacts with multiple signal transduction pathways. Notably it engages in the MAPK/ERK pathway which plays a critical role in transmitting growth signals from the cell surface to the nucleus. Moreover EGR4 influences the PI3K/AKT pathway related to cell survival and metabolism. These pathways connect EGR4 with other proteins such as c-JUN and CREB important for gene regulation and cellular response mechanisms.

The dysregulation of EGR4 has been associated with certain neurological disorders and cancers. In particular aberrant expression of EGR4 links to Alzheimer's disease where it might contribute to neuronal damage and impaired cognitive functions. Additionally EGR4 involvement appears in the progression of testicular tumors indicating its role in cell proliferation and malignancy. EGR4's interaction with p53 a prominent tumor suppressor protein could exacerbate or mitigate these disease processes by influencing apoptosis or cell cycle regulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
See full target information Early growth response protein 4
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Brain and behavior 15:e70377 PubMed40320842

2025

Analysis and Identification of Therapeutic Targets for Neuronal Regeneration After Ischemic Stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Li Min,Li Guo,Zhenyu Wang,Lei Zhao,Chenglong Shi,Xiaoyong Liu,Zhen Wang,Fei-Fei Shang,Jiaping Wang

American journal of translational research 16:755-767 PubMed38586100

2024

Screening of potential biomarkers in propofol-induced neurotoxicity via bioinformatics prediction and experimental verification.

Applications

Unspecified application

Species

Unspecified reactive species

Tianping He,Jianfeng Huang,Bo Peng,Mianhui Wang,Qiuhao Shui,Liang Cai

JCI insight 6: PubMed33373327

2021

The DNA repair protein ATM as a target in autism spectrum disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Lara Pizzamiglio,Elisa Focchi,Clara Cambria,Luisa Ponzoni,Silvia Ferrara,Francesco Bifari,Genni Desiato,Nicoletta Landsberger,Luca Murru,Maria Passafaro,Mariaelvina Sala,Michela Matteoli,Elisabetta Menna,Flavia Antonucci

Biochimie 149:62-70 PubMed29580816

2018

Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway.

Applications

WB

Species

Rat

Rui-Na Niu,Xiao-Ping Shang,Jun-Fang Teng
View all publications
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