AB81681

Anti-Elafin/ESI antibody [TRAB2F]

Name: Anti-Elafin/ESI antibody [TRAB2F] (ab81681) | Abcam
Brand: Abcam Limited
SKU: AB81681
Price: 525 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal Elafin/ESI antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PI3 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

WAP3, WFDC14, PI3, Elafin, Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, ESI, PI-3, SKALP

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TRAB2F

Isotype

IgG2b

Carrier free

Reacts with

Human

Applications

WB, IHC-P, ELISA

applications

Immunogen

Synthetic Peptide within Human PI3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P19957

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elafin also known as ESI or ESI protein is a small serine protease inhibitor with a molecular mass of around 6 kDa. This protein produced by epithelial cells resides predominantly in the skin lungs and other mucosal surfaces. The Elafin protein plays an important mechanical role in inhibiting neutrophil elastase and proteinase 3. It contributes to the regulation of protease activity within tissues controlling inflammation and repair processes.

Biological function summary

Elafin interacts intimately with protease inhibitors to guard tissues against excessive proteolytic damage. It does not typically form large complexes but functions as part of the innate immune defense. This protein helps to neutralize the action of neutrophil elastase which can help maintain the integrity of connective tissue extracellular matrix. Despite its standalone function Elafin's activity serves in tandem with other inhibitors in the protease-antiprotease balance.

Pathways

Elafin integrates prominently into the proteolytic and inflammatory pathways. It functions particularly in the inflammation and immune response pathways coordinating with proteins like secretory leukocyte protease inhibitor (SLPI) and alpha-1 antitrypsin. Elafin inhibits enzymes that degrade connective tissue components. Therefore it plays an important role in modulating inflammatory responses and tissue remodeling post-injury.

Connections between Elafin and conditions such as chronic obstructive pulmonary disease (COPD) and psoriasis appear significant. These diseases relate to abnormal protease activity and chronic inflammation where Elafin's inhibitory function can be affected or diminished. Studies have shown that altered Elafin levels link with these diseases alongside proteins like neutrophil elastase and matrix metalloproteinases which contribute to tissue damage. Researchers continue to explore Elafin's therapeutic potential in managing such inflammatory conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed : 29483648).

See full target information PI3

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of inflammation research 13:233-243 PubMed32547155

2020

Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Renata Curciarello,Toni Sobande,Samantha Jones,Paolo Giuffrida,Antonio Di Sabatino,Guillermo H Docena,Thomas T MacDonald,Klaartje Kok

Journal of reproductive immunology 141:103136 PubMed32485443

2020

Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes.

Applications

Unspecified application

Species

Unspecified reactive species

Fatemeh Zakizadeh,Hamidreza Mahmoudzadeh-Sagheb,Azam Asemi-Rad,Marzieh Ghasemi,Bita Moudi,Nadia Sheibak,Zahra Asadikalameh,Zahra Heidari

Experimental dermatology 27:463-469 PubMed28833576

2017

Towards the development of a RNAi-based topical treatment for psoriasis: Proof-of-concept in a 3D psoriasis skin model.

Applications

Unspecified application

Species

Unspecified reactive species

Eline Desmet,Mireille Van Gele,Lynda Grine,Katrien Remaut,Jo Lambert

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Elafin/ESI antibody [TRAB2F]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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