AB217356

Anti-Elastin antibody

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(22 Publications )

Rabbit Polyclonal Elastin antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 22 publications. Immunogen corresponding to Synthetic Peptide within Human ELN aa 750 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Elastin, Tropoelastin, ELN

2 Images

Western blot - Anti-Elastin antibody (AB217356)

WB

Supplier Data

Western blot - Anti-Elastin antibody (AB217356)

All lanes:

Western blot - Anti-Elastin antibody (ab217356) at 1/300 dilution

All lanes:

mouse lung lysate

Secondary

All lanes:

conjugated secondary at 1/10000 dilution

Predicted band size: 68 kDa

false

Western blot - Anti-Elastin antibody (AB217356)

WB

Supplier Data

Western blot - Anti-Elastin antibody (AB217356)

All lanes:

Western blot - Anti-Elastin antibody (ab217356) at 1/200 dilution

Lane 1:

mouse intestine lysate

Lane 2:

rat lung lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Mouse

Applications

WB

Immunogen

Synthetic Peptide within Human ELN aa 750 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elastin also known as elastin protein is an essential component of the extracellular matrix known for imparting elasticity and resilience to tissues. With a molecular mass of approximately 60-70 kDa some scientists may also refer to it as elastin et. Elastin is expressed in elastic tissues such as the skin lungs and blood vessels. These tissues require the elastic properties provided by elastin. Additionally elastin forms the core of elastic fibers surrounded by a sheath of microfibrils.

Biological function summary

Elastin provides mechanical support and elasticity to tissues. It does so by being part of elastic fibers playing an important role in many connective tissue structures. The unique ability to stretch and return to its original shape allows tissues to resume their shape after stretching or contracting. Elastin is not part of larger protein complexes but interacts with other matrix proteins such as fibrillin to form a fibrous network required for the structural integrity of elastic tissues.

Pathways

Elastin plays an integral role in the extracellular matrix remodeling pathway which is important for maintaining tissue structure and function. It also participates in the TGF-beta signaling pathway where elastin interacts indirectly with proteins such as fibrillin-1 and fibulin. These interactions influence cellular processes like proliferation and differentiation highlighting elastin's involvement in both maintaining tissue elasticity and cell signaling.

Elastin is linked to pathologies like Williams-Beuren syndrome and cutis laxa. Williams-Beuren syndrome associated with elastin deletions leads to cardiovascular issues while cutis laxa results in reduced elasticity of the skin due to elastin mutations. In these conditions elastin interacts with proteins such as fibrillin and fibulin contributing to the observed clinical manifestations. Understanding these interactions helps in diagnosing and developing therapeutic approaches for such disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).

See full target information ELN

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Publications (22)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell communication and signaling 19:e70048 PubMed41040887

2025

Targeting the PI3K/Akt/NF-κB axis: Cluster of differentiation 5-like-mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm.

Applications

Unspecified application

Species

Unspecified reactive species

Hemoren Yi,Nan Liu,Zhengyang Wu,Lei Li,Tingting Li,Qixiang Liu,Man Duan,Taihu Wan

Frontiers in medicine 12:1612452 PubMed40837574

2025

Expression of extracellular matrix protein in advanced keratoconus and the normal human cornea.

Applications

Unspecified application

Species

Unspecified reactive species

Fatima Habroosh,Perla Filippini,Ahmed Al Saadi,Shady Soliman,Burcin Kepez Yildiz,Prity Sahay,Dalia G Said,Harminder S Dua

Biomedicines 12: PubMed38540123

2024

Antiadhesive Hyaluronic Acid-Based Wound Dressings Promote Wound Healing by Preventing Re-Injury: An In Vivo Investigation.

Applications

Unspecified application

Species

Unspecified reactive species

Da Som Kim,Keum-Yong Seong,Hyeseon Lee,Min Jae Kim,Sung-Min An,Jea Sic Jeong,So Young Kim,Hyeon-Gu Kang,Sangsoo Jang,Dae-Youn Hwang,Sung-Baek Seo,Seong-Min Jo,Seung Yun Yang,Beum-Soo An

Disease models & mechanisms 16: PubMed37905384

2023

Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Maria F Suarez,Heather M Schmitt,Megan S Kuhn,TeddiJo Watkins,Kristyn M Hake,Tara Weisz,Edward J Flynn,Michael H Elliott,Michael A Hauser,W Daniel Stamer

International journal of nanomedicine 18:627-639 PubMed36777816

2023

Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwei Zhang,Jiawei Zhuang,Daohan Sun,Qingwei Ding,Hui Zheng,Haixiang Li,Xiaoyu Zhang,Yaming Du,Teng Ma,Qingyou Meng

Tissue engineering. Part A 29:187-199 PubMed36641641

2023

Targeting Epidermal Growth Factor Receptor to Stimulate Elastic Matrix Regenerative Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Simran Dayal,Thomas Broekelmann,Robert P Mecham,Anand Ramamurthi

Tissue engineering. Part A 29:225-243 PubMed36597287

2023

Sodium Nitroprusside Stimulation of Elastic Matrix Regeneration by Aneurysmal Smooth Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Suraj Bastola,Chandrasekhar Kothapalli,Anand Ramamurthi

Molecular medicine reports 25: PubMed35169867

2022

Inhibitory effect of membrane‑free stem cell components derived from adipose tissues on skin inflammation in keratinocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Sang Eun Ha,Preethi Vetrivel,Seong Min Kim,Pritam Bhagwan Bhosale,Hun Hwan Kim,Jung Eun Pak,Jeong Doo Heo,Young Sil Kim,Gon Sup Kim

World journal of gastroenterology 27:6615-6630 PubMed34754156

2021

Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Jing-Chun Qin,Wei-Tao Yu,Hui-Xuan Li,Yu-Qi Liang,Fei-Fei Nong,Bin Wen

Asian Pacific journal of allergy and immunology : PubMed34542300

2021

The role of anti-elastin antibodies in a mouse model of asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoshige Wakayama,Kumiya Sugiyama,Shingo Tokita,Hajime Arifuku,Naotatsu Otsuji,Kei Sugitate,Takayoshi Owada,Kenya Koyama,Hirokuni Hirata,Masafumi Arima,Yasutsugu Fukushima

View all publications

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Product promise

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