AB217356

Anti-Elastin antibody

Name: Anti-Elastin antibody (ab217356) | Abcam
Brand: Abcam Limited
SKU: AB217356
Price: 515 USD
Availability: InStock

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(14 Publications)

Rabbit Polyclonal Elastin antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 14 publications. Immunogen corresponding to Synthetic Peptide within Human ELN aa 750 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Elastin, Tropoelastin, ELN

2 Images

Supplier Data

Western blot - Anti-Elastin antibody (AB217356)

All lanes:

Western blot - Anti-Elastin antibody (ab217356) at 1/300 dilution

All lanes:

mouse lung lysate

Secondary

All lanes:

conjugated secondary at 1/10000 dilution

Predicted band size: 68 kDa

false

Supplier Data

Western blot - Anti-Elastin antibody (AB217356)

All lanes:

Western blot - Anti-Elastin antibody (ab217356) at 1/200 dilution

Lane 1:

mouse intestine lysate

Lane 2:

rat lung lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Mouse

Applications

applications

Immunogen

Synthetic Peptide within Human ELN aa 750 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P15502

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elastin also known as elastin protein is an essential component of the extracellular matrix known for imparting elasticity and resilience to tissues. With a molecular mass of approximately 60-70 kDa some scientists may also refer to it as elastin et. Elastin is expressed in elastic tissues such as the skin lungs and blood vessels. These tissues require the elastic properties provided by elastin. Additionally elastin forms the core of elastic fibers surrounded by a sheath of microfibrils.

Biological function summary

Elastin provides mechanical support and elasticity to tissues. It does so by being part of elastic fibers playing an important role in many connective tissue structures. The unique ability to stretch and return to its original shape allows tissues to resume their shape after stretching or contracting. Elastin is not part of larger protein complexes but interacts with other matrix proteins such as fibrillin to form a fibrous network required for the structural integrity of elastic tissues.

Pathways

Elastin plays an integral role in the extracellular matrix remodeling pathway which is important for maintaining tissue structure and function. It also participates in the TGF-beta signaling pathway where elastin interacts indirectly with proteins such as fibrillin-1 and fibulin. These interactions influence cellular processes like proliferation and differentiation highlighting elastin's involvement in both maintaining tissue elasticity and cell signaling.

Elastin is linked to pathologies like Williams-Beuren syndrome and cutis laxa. Williams-Beuren syndrome associated with elastin deletions leads to cardiovascular issues while cutis laxa results in reduced elasticity of the skin due to elastin mutations. In these conditions elastin interacts with proteins such as fibrillin and fibulin contributing to the observed clinical manifestations. Understanding these interactions helps in diagnosing and developing therapeutic approaches for such disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).

See full target information ELN

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Disease models & mechanisms 16: PubMed37905384

2023

Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Maria F Suarez,Heather M Schmitt,Megan S Kuhn,TeddiJo Watkins,Kristyn M Hake,Tara Weisz,Edward J Flynn,Michael H Elliott,Michael A Hauser,W Daniel Stamer

International journal of nanomedicine 18:627-639 PubMed36777816

2023

Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwei Zhang,Jiawei Zhuang,Daohan Sun,Qingwei Ding,Hui Zheng,Haixiang Li,Xiaoyu Zhang,Yaming Du,Teng Ma,Qingyou Meng

World journal of gastroenterology 27:6615-6630 PubMed34754156

2021

Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Jing-Chun Qin,Wei-Tao Yu,Hui-Xuan Li,Yu-Qi Liang,Fei-Fei Nong,Bin Wen

Asian Pacific journal of allergy and immunology : PubMed34542300

2021

The role of anti-elastin antibodies in a mouse model of asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoshige Wakayama,Kumiya Sugiyama,Shingo Tokita,Hajime Arifuku,Naotatsu Otsuji,Kei Sugitate,Takayoshi Owada,Kenya Koyama,Hirokuni Hirata,Masafumi Arima,Yasutsugu Fukushima

Frontiers in endocrinology 12:693977 PubMed34484115

2021

An Study on Extracellular Vesicles From Adipose-Derived Mesenchymal Stem Cells in Protecting Stress Urinary Incontinence Through MicroRNA-93/F3 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Wang,Yali Wang,Yuancui Xiang,Jinping Ma,Hui Zhang,Jingfang Dai,Yanan Hou,Yupei Yang,Jingru Ma,Hongjuan Li

Cell reports 35:109223 PubMed34107247

2021

Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality.

Applications

Unspecified application

Species

Unspecified reactive species

Svenja C Schüler,Joanna M Kirkpatrick,Manuel Schmidt,Deolinda Santinha,Philipp Koch,Simone Di Sanzo,Emilio Cirri,Martin Hemberg,Alessandro Ori,Julia von Maltzahn

Aging 13:3045-3059 PubMed33460398

2021

Transplantation of bone marrow-derived mesenchymal stem cells with silencing of microRNA-138 relieves pelvic organ prolapse through the FBLN5/IL-1β/elastin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Zhao,Qing Sun,Yazhou Fan,Xinming Hu,Linyu Li,Junmin Wang,Shihong Cui

Andrologia 52:e13831 PubMed32986908

2020

Intratunical injection of human urine-derived stem cells derived exosomes prevents fibrosis and improves erectile function in a rat model of Peyronie's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Qiyun Yang,Wanmei Chen,Dayu Han,Chi Zhang,Yun Xie,Xiangzhou Sun,Guihua Liu,Chunhua Deng

Frontiers in cell and developmental biology 8:307 PubMed32671057

2020

Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System.

Applications

Unspecified application

Species

Unspecified reactive species

Kensuke Kataoka,Ryota Kurimoto,Hiroki Tsutsumi,Tomoki Chiba,Tomomi Kato,Kana Shishido,Mariko Kato,Yoshiaki Ito,Yuichiro Cho,Osamu Hoshi,Ayako Mimata,Yuriko Sakamaki,Ryo Nakamichi,Martin K Lotz,Keiji Naruse,Hiroshi Asahara

American journal of physiology. Heart and circulat 318:H1219-H1232 PubMed32216612

2020

Sex differences in the structure and function of rat middle cerebral arteries.

Applications

Unspecified application

Species

Unspecified reactive species

Shaoxun Wang,Huawei Zhang,Yedan Liu,Longyang Li,Ya Guo,Feng Jiao,Xing Fang,Joshua R Jefferson,Man Li,Wenjun Gao,Ezekiel Gonzalez-Fernandez,Rodrigo O Maranon,Mallikarjuna R Pabbidi,Ruen Liu,Barbara T Alexander,Richard J Roman,Fan Fan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Elastin antibody

Western blot - Anti-Elastin antibody (AB217356)

Western blot - Anti-Elastin antibody (AB217356)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

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