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AB9519

Anti-Elastin antibody [BA-4]

4

(10 Reviews)

|

(42 Publications)

Anti-Elastin antibody [BA-4] (ab9519) is a mouse monoclonal antibody detecting Elastin in Western Blot. Suitable for Human.

- Over 30 publications
- Trusted since 2002

View Alternative Names

Elastin, Tropoelastin, ELN

1 Images
Western blot - Anti-Elastin antibody [BA-4] (AB9519)
  • WB

Unknown

Western blot - Anti-Elastin antibody [BA-4] (AB9519)

All lanes:

Western blot - Anti-Elastin antibody [BA-4] (ab9519) at 0.51 µg/mL

All lanes:

Human skin tissue lysate - total protein (<a href='/en-us/products/unavailable/human-skin-tissue-lysate-total-protein-ab30166'>ab30166</a>) at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

Predicted band size: 68 kDa

Observed band size: 55 kDa,70 kDa

true

Exposure time: 20min

  • Carrier free

    Anti-Elastin antibody [BA-4] - BSA and Azide free

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BA-4

Isotype

IgG1

Light chain type

unknown

Carrier free

No

Reacts with

Human

Applications

WB

applications

Epitope

BA-4 is specific for a chemotactically active epitope composed of valine, glycine, alanine, and proline in a molar ratio of approximately 2:2:1:1 (PMID 2429696).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.51 µg/mL", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "1-5 µg/mL", "IHCFr-species-notes": "<p></p>" }, "Cat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Dog": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Goat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Pig": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Sheep": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Product details

What is this antibody validated in?
Anti-Elastin antibody [BA-4] (ab9519) is a mouse monoclonal antibody and is validated for use in Western Blot (WB) in Human samples.

What is the molecular weight of Elastin?
Anti-Elastin [BA-4] (ab9519) specifically detects a band for Elastin (UniProt: P15502) at a molecular weight of 68kDa.

Trusted by the scientific community
Anti-Elastin [BA-4] (ab9519) was first used in a scientific publication in 2002 and has been cited over 30 times in peer-reviewed journals.

Reviewed by scientists
Anti-Elastin [BA-4] (ab9519) has over 5 independent reviews from customers.

Other related products
We have a range of other formats of antibody clone [BA-4] also available for your convenience: ab9519, Carrier free - ab269450

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elastin also known as elastin protein is an essential component of the extracellular matrix known for imparting elasticity and resilience to tissues. With a molecular mass of approximately 60-70 kDa some scientists may also refer to it as elastin et. Elastin is expressed in elastic tissues such as the skin lungs and blood vessels. These tissues require the elastic properties provided by elastin. Additionally elastin forms the core of elastic fibers surrounded by a sheath of microfibrils.
Biological function summary

Elastin provides mechanical support and elasticity to tissues. It does so by being part of elastic fibers playing an important role in many connective tissue structures. The unique ability to stretch and return to its original shape allows tissues to resume their shape after stretching or contracting. Elastin is not part of larger protein complexes but interacts with other matrix proteins such as fibrillin to form a fibrous network required for the structural integrity of elastic tissues.

Pathways

Elastin plays an integral role in the extracellular matrix remodeling pathway which is important for maintaining tissue structure and function. It also participates in the TGF-beta signaling pathway where elastin interacts indirectly with proteins such as fibrillin-1 and fibulin. These interactions influence cellular processes like proliferation and differentiation highlighting elastin's involvement in both maintaining tissue elasticity and cell signaling.

Elastin is linked to pathologies like Williams-Beuren syndrome and cutis laxa. Williams-Beuren syndrome associated with elastin deletions leads to cardiovascular issues while cutis laxa results in reduced elasticity of the skin due to elastin mutations. In these conditions elastin interacts with proteins such as fibrillin and fibulin contributing to the observed clinical manifestations. Understanding these interactions helps in diagnosing and developing therapeutic approaches for such disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
See full target information ELN
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Publications (42)

Recent publications for all applications. Explore the full list and refine your search

Materials today. Bio 34:102239 PubMed40917518

2025

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models.

Applications

Unspecified application

Species

Unspecified reactive species

Roman Krymchenko,Nancy Avila-Martinez,Merel Gansevoort,Gert-Jan Bakker,Madalena L N P Gomes,Marcel Vlig,Elly M M Versteeg,Bouke K H L Boekema,Toin H van Kuppevelt,Willeke F Daamen

Journal of cosmetic dermatology 24:e70306 PubMed40642809

2025

Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter.

Applications

Unspecified application

Species

Unspecified reactive species

John Ivarsson,Xi Yan,Anna Guiotto,Alessandra Pecorelli,Mariáurea Matias Sarandy,Stephen Lynch,Sara Anderias,Hina Choudhary,Stacy White,Francesca Ferrara,Giuseppe Valacchi

Frontiers in bioengineering and biotechnology 13:1606615 PubMed40606914

2025

Acellular porcine placental membranes as a novel biomaterial for tissue repair applications.

Applications

Unspecified application

Species

Unspecified reactive species

Gustavo Henrique Doná Rodrigues Almeida,Luan Stefani Lima,Mariana Sversut Gibbin,Beatriz Lopomo,Rafael Oliveira Bergamo,Raquel Souza da Silva,Giovanna Vitória Consani Santos,Bruna Gomes Silva,Isabela Paulillo D'Onofrio,Henrique Dos Santos,Lediane Pedroso Silva,Tais da Silva,Henrique Lança Fuzeti,Bianca Fuzeti Candian,Thais Naomi Gonçalves Nesiyama,João Victor Damin,Claudio Guilherme de Assis Oliveira,Lucas Paulo Jacinto Saavedra,Guilherme Henrique Gonçalves de Almeida,Douglas Lopes de Almeida,Jaqueline de Carvalho Rinaldi,Francielle Sato,Mauro Luciano Baesso,Luzmarina Hernandes,Flávio Vieira Meirelles,Rose Eli Grassi Rici,Durvanei Augusto Maria,Paulo Cezar de Freitas Mathias,Ana Claudia Oliveira Carreira

Bioengineering (Basel, Switzerland) 12: PubMed39851326

2025

From Cartilage to Matrix: Protocols for the Decellularization of Porcine Auricular Cartilage.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Caroline Dos Santos,Livia Maria Barbosa de Andrade,Raí André Querino Candelária,Juliana Casanovas de Carvalho,Maria Carolina Miglino Valbão,Rodrigo da Silva Nunes Barreto,Marcelo Domingues de Faria,Rogerio Leone Buchaim,Daniela Vieira Buchaim,Maria Angelica Miglino

Biomimetics (Basel, Switzerland) 9: PubMed39056823

2024

Region-Specific Decellularization of Porcine Uterine Tube Extracellular Matrix: A New Approach for Reproductive Tissue-Engineering Applications.

Applications

Unspecified application

Species

Unspecified reactive species

Gustavo Henrique Doná Rodrigues Almeida,Raquel Souza da Silva,Mariana Sversut Gibin,Victória Hellen de Souza Gonzaga,Henrique Dos Santos,Rebeca Piatniczka Igleisa,Leticia Alves Fernandes,Iorrane Couto Fernandes,Thais Naomi Gonçalves Nesiyama,Francielle Sato,Mauro Luciano Baesso,Luzmarina Hernandes,Jaqueline de Carvalho Rinaldi,Flávio Vieira Meirelles,Claudete S Astolfi-Ferreira,Antonio José Piantino Ferreira,Ana Claudia Oliveira Carreira

International journal of molecular sciences 24: PubMed38003660

2023

Improved Reversion of Calcifications in Porcine Aortic Heart Valves Using Elastin-Targeted Nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Anja Feldmann,Yvonne Nitschke,Franziska Linß,Dennis Mulac,Sina Stücker,Jessica Bertrand,Insa Buers,Klaus Langer,Frank Rutsch

Cells 12: PubMed37508528

2023

Perfusion and Ultrasonication Produce a Decellularized Porcine Whole-Ovary Scaffold with a Preserved Microarchitecture.

Applications

Unspecified application

Species

Unspecified reactive species

Gustavo Henrique Doná Rodrigues Almeida,Leandro Norberto da Silva-Júnior,Mariana Sversut Gibin,Henrique Dos Santos,Bianca de Oliveira Horvath-Pereira,Leticia Beatriz Mazo Pinho,Mauro Luciano Baesso,Francielle Sato,Luzmarina Hernandes,Charles R Long,Luciana Relly,Maria Angelica Miglino,Ana Claudia Oliveira Carreira

Journal of tissue engineering and regenerative medicine 2023:9985334 PubMed40226415

2023

Effect of Cadherin-11 on the Proliferation, Migration, and ECM Synthesis of Chondrocyte.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Li,Hang Shi,Xia Liu,Haiyue Jiang

Frontiers in cell and developmental biology 10:1007265 PubMed36268506

2022

Improved contractile potential in detrusor microtissues from pediatric patients with end stage lower urinary tract dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Tim Gerwinn,Souzan Salemi,Larissa J Schori,Dafni Planta,Daniel Eberli,Maya Horst

Frontiers in physiology 13:990801 PubMed36187759

2022

Human lymph node degeneration in the thoracic region: A morphometric and immunohistochemical analysis using surgically obtained specimens.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe-Wu Jin,Masaya Aoki,Kazuhiro Ueda,Go Kamimura,Aya Takeda-Harada,Gen Murakami,Masami Sato
View all publications
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