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AB72603

Anti-ELAVL2 + ELAVL4 antibody

4

(1 Review)

|

(3 Publications)

Rabbit Polyclonal ELAVL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ELAVL2.

View Alternative Names

HUB, ELAVL2, ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, Nervous system-specific RNA-binding protein Hel-N1, HuB, HUD, PNEM, ELAVL4, ELAV-like protein 4, Hu-antigen D, Paraneoplastic encephalomyelitis antigen HuD, HuD

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ELAVL2 + ELAVL4 antibody (AB72603)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ELAVL2 + ELAVL4 antibody (AB72603)

ab72603, at 1/500 dilution, staining HepG2 cells in the absence or presence of the immunising peptide.

Western blot - Anti-ELAVL2 + ELAVL4 antibody (AB72603)
  • WB

Unknown

Western blot - Anti-ELAVL2 + ELAVL4 antibody (AB72603)

All lanes:

Western blot - Anti-ELAVL2 + ELAVL4 antibody (ab72603) at 1/500 dilution

Lane 1:

Extracts from HUVEC cells at 5 µg

Lane 2:

Extracts from Jurkat cells at 5 µg

Lane 3:

Extracts from Jurkat cells at 5 µg with immunising peptide

Predicted band size: 40 kDa

Observed band size: 40 kDa,75 kDa,80 kDa,85 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human ELAVL2. The exact immunogen used to generate this antibody is proprietary information.

Q12926

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ELAVL2 and ELAVL4 also known as HuB and HuD are RNA-binding proteins with a molecular weight of approximately 36-42 kDa. These proteins are part of the ELAV (Embryonic Lethal Abnormal Vision) family playing an important role in the post-transcriptional regulation of gene expression. ELAVL2 and ELAVL4 are expressed predominantly in the neurons where they bind to AU-rich elements in the 3' untranslated regions of target mRNAs influencing their stability and translation.
Biological function summary

ELAVL2 and ELAVL4 stabilize mRNAs and modulate their translation. They participate actively in the neuronal differentiation processes and synaptic plasticity. The proteins do not typically form large complexes but instead work as vital regulators of neuronal mRNA. Their activity leads to the proper expression of target genes facilitating the development and function of the nervous system.

Pathways

RNA-binding proteins like ELAVL2 and ELAVL4 are involved in the regulation of neural pathways and synaptic communication. They play a major role in the mRNA processing and transport pathways. Furthermore they work closely with proteins such as FMRP (Fragile X Mental Retardation Protein) and other ELAV family members coordinating the stability of specific transcripts necessary for synaptic function and plasticity.

ELAVL2 and ELAVL4 show significant relevance to neurodegenerative diseases and cancer. Altered expression or malfunction of these proteins directly impacts conditions like Alzheimer's disease and certain types of neural tumors. These proteins' association with dysfunctional mRNA processing and regulation connects them to other disease-related proteins such as Tau in Alzheimer's highlighting their influence on pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity).
See full target information ELAVL2

Additional targets

ELAVL4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cells 12: PubMed37681934

2023

MicroRNA-375 Is Induced during Astrocyte-to-Neuron Reprogramming and Promotes Survival of Reprogrammed Neurons when Overexpressed.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanyu Chen,Ivan Sokirniy,Xin Wang,Mei Jiang,Natalie Mseis-Jackson,Christine Williams,Kristopher Mayes,Na Jiang,Brendan Puls,Quansheng Du,Yang Shi,Hedong Li

Environmental toxicology 36:1070-1079 PubMed33522089

2021

SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Sizhen Li,Qingsong Yang,Zixiu Zhou,Min Fu,Xiaodong Yang,Kuanxiao Hao,Yating Liu

Cell stem cell 22:684-697.e9 PubMed29727680

2018

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Anindita Sarkar,Arianna Mei,Apua C M Paquola,Shani Stern,Cedric Bardy,Jason R Klug,Stacy Kim,Neda Neshat,Hyung Joon Kim,Manching Ku,Maxim N Shokhirev,David H Adamowicz,Maria C Marchetto,Roberto Jappelli,Jennifer A Erwin,Krishnan Padmanabhan,Matthew Shtrahman,Xin Jin,Fred H Gage
View all publications
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Product promise

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