Anti-ELAVL2 + ELAVL4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ELAVL2 and ELAVL4 also known as HuB and HuD are RNA-binding proteins with a molecular weight of approximately 36-42 kDa. These proteins are part of the ELAV (Embryonic Lethal Abnormal Vision) family playing an important role in the post-transcriptional regulation of gene expression. ELAVL2 and ELAVL4 are expressed predominantly in the neurons where they bind to AU-rich elements in the 3' untranslated regions of target mRNAs influencing their stability and translation.

Biological function summary

ELAVL2 and ELAVL4 stabilize mRNAs and modulate their translation. They participate actively in the neuronal differentiation processes and synaptic plasticity. The proteins do not typically form large complexes but instead work as vital regulators of neuronal mRNA. Their activity leads to the proper expression of target genes facilitating the development and function of the nervous system.

Pathways

RNA-binding proteins like ELAVL2 and ELAVL4 are involved in the regulation of neural pathways and synaptic communication. They play a major role in the mRNA processing and transport pathways. Furthermore they work closely with proteins such as FMRP (Fragile X Mental Retardation Protein) and other ELAV family members coordinating the stability of specific transcripts necessary for synaptic function and plasticity.

Associated diseases and disorders

ELAVL2 and ELAVL4 show significant relevance to neurodegenerative diseases and cancer. Altered expression or malfunction of these proteins directly impacts conditions like Alzheimer's disease and certain types of neural tumors. These proteins' association with dysfunctional mRNA processing and regulation connects them to other disease-related proteins such as Tau in Alzheimer's highlighting their influence on pathogenesis.