Rabbit Polyclonal ELF5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELF5 aa 150-250.
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- Frontiers in cell and developmental biology 9:6477632021EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYulang Huang,Lifang Chen,Zongming Feng,Weixin Chen,Shaodi Yan,Rongfeng Yang,Jian Xiao,Jiajia Gao,Debao Zhang,Xiao KePubMed 34055778
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ELF5 aa 150-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UKW6
Reactivity data
Select an application| ICC/IF | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Cow | Predicted |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Target data
Function
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
Alternative names
ESE2, ELF5, ETS-related transcription factor Elf-5, E74-like factor 5, Epithelium-restricted ESE-1-related Ets factor, Epithelium-specific Ets transcription factor 2, ESE-2
Recommended products
Rabbit Polyclonal ELF5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELF5 aa 150-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ELF5 aa 150-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UKW6
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ELF5 also known as E74 Like ETS Transcription Factor 5 is a transcription factor with a mass of approximately 27 kDa. It belongs to the ETS family and plays a role in regulating gene expression by binding to specific DNA sequences. ELF5 localizes mainly in epithelial tissues where it influences development and differentiation. This targeting involves critical cellular processes particularly affecting mammary gland and placental development.
- Biological function summary
ELF5 plays a significant role in maintaining the balance between cellular proliferation and differentiation. It operates within specific protein complexes to modulate the luminal epithelial cell fate in the mammary gland. ELF5 regulates critical genes responsible for alveolar development contributing to normal lactation. In placental tissues it affects trophoblast differentiation and normal placental function reflecting its impact on fetal development.
- Pathways
ELF5 actively participates in pathways involving hormone response and epithelial cell differentiation. It interacts closely with proteins such as GATA3 within these pathways which help regulate luminal cell differentiation in the mammary gland. ELF5 also participates in the Wnt signaling pathway demonstrating its multifaceted roles by influencing cell fate decisions and maintaining epithelial homeostasis.
- Associated diseases and disorders
ELF5 shows connections to breast cancer and placental disorders. Changes in ELF5 expression can impact breast cancer progression by altering epithelial cell states emphasizing its predictive role in cancer biology. Aberrant ELF5 levels may contribute to conditions like pre-eclampsia through its association with critical proteins such as GATA3 affecting normal placental function and development.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunocytochemistry/ Immunofluorescence - Anti-ELF5 antibody (ab222251)
4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized RT4 (human urinary bladder cancer cell line) cells stained for ELF5 (green) using ab222251 at 4 μg/ml in ICC/IF.
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