Anti-Elongation of very long chain fatty acids protein 3 antibody
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(1 Publication)
Rabbit Polyclonal Elongation of very long chain fatty acids protein 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELOVL3 aa 1-50.
View Alternative Names
CIG30, ELOVL3, Very long chain fatty acid elongase 3, 3-keto acyl-CoA synthase ELOVL3, Cold-inducible glycoprotein of 30 kDa, ELOVL fatty acid elongase 3, Elongation of very long chain fatty acids protein 3, Very long chain 3-ketoacyl-CoA synthase 3, Very long chain 3-oxoacyl-CoA synthase 3, ELOVL FA elongase 3
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-Elongation of very long chain fatty acids protein 3 antibody (AB253016)
PFA-fixed, Triton X-100 permeabilized SiHa (Human cervical carcinoma cell line) cells stained for Elongation of very long chain fatty acids protein 3 (green) using ab253016 at 4 μg/ml in ICC/IF.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Elongation of very long chain fatty acids protein 3 antibody (AB253016)
Formalin-fixed, paraffin-embedded human tonsil tissue shows absence of immunoreactivity for ELOVL3 when incubated with ab253016 at a 1/2500 dilution (negative control).
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Elongation of very long chain fatty acids protein 3 antibody (AB253016)
Formalin-fixed, paraffin-embedded human liver tissue shows absence of immunoreactivity for ELOVL3 when incubated with ab253016 at a 1/2500 dilution (negative control).
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Elongation of very long chain fatty acids protein 3 antibody (AB253016)
Formalin-fixed, paraffin-embedded human skin tissue stained for ELOVL3 with ab253016 at a 1/2500 dilution in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Elongation of very long chain fatty acids protein 3 antibody (AB253016)
Formalin-fixed, paraffin-embedded human pancreas tissue shows absence of immunoreactivity for ELOVL3 when incubated with ab253016 at a 1/2500 dilution (negative control).
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Biological function summary
The synthesis and regulation of very long chain fatty acids rely heavily on ELOVL3. The protein is part of a complex that includes other elongation enzymes important for lipid metabolism. Through its action in lipid biosynthesis ELOVL3 plays an essential role in maintaining cellular membrane integrity and signaling molecules that rest within the lipid categories. This underlines its importance in energy storage and consumption particularly in adipose tissues where it contributes to the synthesis of lipids necessary for efficient thermal insulation and protection.
Pathways
Long chain fatty acid metabolism places significant importance on ELOVL3. It aligns itself within the fatty acid elongation pathway which serves as an integral section of the overall lipid metabolism pathway. This process involves interaction with other elongase proteins like ELOVL1 revealing a network of collaborative pathway members performing tasks necessary for elongating fatty acids properly. This elongation impacts processes like synthesis of essential neutral lipids and the development of ceramides that affect cellular communication.
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Publications (1)
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European journal of clinical investigation 51:e13541 PubMed33797091
2021
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