AB74941

Anti-ELOVL1/SSC1 antibody

Name: Anti-ELOVL1/SSC1 antibody (ab74941) | Abcam
Brand: Abcam Limited
SKU: AB74941
Price: 520 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal ELOVL1/SSC1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ELOVL1.

View Alternative Names

SSC1, CGI-88, ELOVL1, Very long chain fatty acid elongase 1, 3-keto acyl-CoA synthase ELOVL1, ELOVL fatty acid elongase 1, Elongation of very long chain fatty acids protein 1, Very long chain 3-ketoacyl-CoA synthase 1, Very long chain 3-oxoacyl-CoA synthase 1, ELOVL FA elongase 1

1 Images

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Western blot - Anti-ELOVL1/SSC1 antibody (AB74941)

All lanes:

Western blot - Anti-ELOVL1/SSC1 antibody (ab74941) at 1/500 dilution

Lane 1:

Extracts from HepG2 cells at 15 µg

Lane 2:

Extracts from Jurkat cells at 15 µg

Lane 3:

Extracts from Jurkat cells at 15 µg with immunizing peptide

Predicted band size: 33 kDa

Observed band size: 36 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human ELOVL1. The exact immunogen used to generate this antibody is proprietary information.

Q9BW60

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ELOVL1 also known as SSC1 functions as an important enzyme involved in the elongation of long-chain fatty acids. It catalyzes the first and rate-limiting step in the fatty acid elongation cycle which involves the condensation of long-chain acyl-CoAs with malonyl-CoA. ELOVL1 has a molecular mass of approximately 31 kDa. You can find it expressed in various tissues but particularly enriched in skin brain and liver tissues. Its expression is not uniformly distributed as it varies depending on cell type and physiology.

Biological function summary

ELOVL1 is responsible for the biosynthesis of very long-chain fatty acids (VLCFAs) which are important components of cell membranes and lipids. ELOVL1 is not known as part of a larger protein complex but contributes significantly to cellular lipid metabolism. VLCFAs are essential to maintaining the integrity and functionality of cell structures and signaling processes supporting various physiological roles within the body. Its regulation affects the homeostasis of lipids impacting numerous cellular processes.

Pathways

ELOVL1 plays an important role in lipid metabolic pathways including the fatty acid elongation and ceramide biosynthesis pathways. It interacts with other enzymes and proteins such as ELOVL4 and ceramide synthases to ensure the production of diverse lipid molecules required for cell survival and proliferation. These pathways facilitate the synthesis and modification of lipids accommodating the needs of dynamic cellular environments.

Faulty ELOVL1 function links with conditions like ichthyosis and neurological disorders. Deficiencies or mutations in ELOVL1 can disrupt the normal production of VLCFAs leading to skin abnormalities and neurological impairments. The protein's association with other lipid metabolism-related proteins like ABCD1 in X-linked adrenoleukodystrophy highlights the broader significance of ELOVL1 in maintaining health and preventing disease. Understanding ELOVL1's role and mechanisms can contribute to therapeutic approaches targeting metabolic and neurodegenerative diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed : 29496980, PubMed : 30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22 : 0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24 : 0 and monounsaturated C24 : 1 sphingolipid synthesis (PubMed : 20937905). Indirectly inhibits RPE65 via production of VLCFAs.

See full target information ELOVL1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 16:16440-53 PubMed26204830

2015

Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts.

Applications

Species

Unspecified reactive species

Weipeng Wang,Qiburi He,Zhixin Guo,Limin Yang,Lili Bao,Wenlei Bao,Xu Zheng,Yanfeng Wang,Zhigang Wang

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ELOVL1/SSC1 antibody

Western blot - Anti-ELOVL1/SSC1 antibody (AB74941)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise