AB204489

Anti-ELOVL1/SSC1 antibody - C-terminal

Name: Anti-ELOVL1/SSC1 antibody - C-terminal (ab204489) | Abcam
Brand: Abcam Limited
SKU: AB204489
Price: 535 USD
Availability: InStock
Rating: 5 (1 reviews)

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(1 Publication)

Rabbit Polyclonal ELOVL1/SSC1 antibody. C-terminal. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELOVL1 aa 250 to C-terminus.

View Alternative Names

SSC1, CGI-88, ELOVL1, Very long chain fatty acid elongase 1, 3-keto acyl-CoA synthase ELOVL1, ELOVL fatty acid elongase 1, Elongation of very long chain fatty acids protein 1, Very long chain 3-ketoacyl-CoA synthase 1, Very long chain 3-oxoacyl-CoA synthase 1, ELOVL FA elongase 1

5 Images

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunocytochemical/Immunofluorescent analysis of parafomaldehyde-fixed, triton x-100 permeabilised human cell line U-2OS cells staining ELOVL1/SSC1 with ab204489 at 4μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human skin tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human kidney tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human colon tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ELOVL1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BW60

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ELOVL1 also known as SSC1 functions as an important enzyme involved in the elongation of long-chain fatty acids. It catalyzes the first and rate-limiting step in the fatty acid elongation cycle which involves the condensation of long-chain acyl-CoAs with malonyl-CoA. ELOVL1 has a molecular mass of approximately 31 kDa. You can find it expressed in various tissues but particularly enriched in skin brain and liver tissues. Its expression is not uniformly distributed as it varies depending on cell type and physiology.

Biological function summary

ELOVL1 is responsible for the biosynthesis of very long-chain fatty acids (VLCFAs) which are important components of cell membranes and lipids. ELOVL1 is not known as part of a larger protein complex but contributes significantly to cellular lipid metabolism. VLCFAs are essential to maintaining the integrity and functionality of cell structures and signaling processes supporting various physiological roles within the body. Its regulation affects the homeostasis of lipids impacting numerous cellular processes.

Pathways

ELOVL1 plays an important role in lipid metabolic pathways including the fatty acid elongation and ceramide biosynthesis pathways. It interacts with other enzymes and proteins such as ELOVL4 and ceramide synthases to ensure the production of diverse lipid molecules required for cell survival and proliferation. These pathways facilitate the synthesis and modification of lipids accommodating the needs of dynamic cellular environments.

Faulty ELOVL1 function links with conditions like ichthyosis and neurological disorders. Deficiencies or mutations in ELOVL1 can disrupt the normal production of VLCFAs leading to skin abnormalities and neurological impairments. The protein's association with other lipid metabolism-related proteins like ABCD1 in X-linked adrenoleukodystrophy highlights the broader significance of ELOVL1 in maintaining health and preventing disease. Understanding ELOVL1's role and mechanisms can contribute to therapeutic approaches targeting metabolic and neurodegenerative diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed : 29496980, PubMed : 30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22 : 0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24 : 0 and monounsaturated C24 : 1 sphingolipid synthesis (PubMed : 20937905). Indirectly inhibits RPE65 via production of VLCFAs.

See full target information ELOVL1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Anatomical record (Hoboken, N.J. : 2007) 305:209-221 PubMed34041863

2021

Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain.

Applications

Unspecified application

Species

Unspecified reactive species

Sameh M Farouk,Ahmed M Abdellatif,Elsayed Metwally

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ELOVL1/SSC1 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise