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AB106633

Anti-ELOVL7 antibody

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(2 Publications)

Rabbit Polyclonal ELOVL7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ELOVL7.

View Alternative Names

Very long chain fatty acid elongase 7, 3-keto acyl-CoA synthase ELOVL7, ELOVL fatty acid elongase 7, Elongation of very long chain fatty acids protein 7, Very long chain 3-ketoacyl-CoA synthase 7, Very long chain 3-oxoacyl-CoA synthase 7, ELOVL FA elongase 7, ELOVL7

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL7 antibody (AB106633)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL7 antibody (AB106633)

ab106633, at 5 μg/ml, staining ELOVL7 in paraffin embedded Human liver tissue by Immunohistochemsitry.

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL7 antibody (AB106633)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL7 antibody (AB106633)

Immunofluorescence of ELOVL7 in Human liver tissue with ab106633 at 20 ug/mL.

Western blot - Anti-ELOVL7 antibody (AB106633)
  • WB

Unknown

Western blot - Anti-ELOVL7 antibody (AB106633)

All lanes:

Western blot - Anti-ELOVL7 antibody (ab106633) at 1 µg/mL

All lanes:

Human liver tissue lysate at 15 µg

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ELOVL7. The exact immunogen used to generate this antibody is proprietary information.

A1L3X0

Specificity

ab106633 is predicted not to crossreact with other ELOVL proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ELOVL7 also known as elongation of very-long-chain fatty acids protein 7 plays a mechanical role in the elongation of very-long-chain fatty acids (VLCFAs). This protein catalyzes the first and rate-limiting step in fatty acid elongation adding two carbon units to acyl-CoAs. ELOVL7 has a molecular mass of approximately 30.9 kDa. The expression of ELOVL7 is observed in various human tissues with higher levels in the liver brain and testes suggesting its significance in these areas.
Biological function summary

ELOVL7 contributes to the synthesis of saturated and unsaturated VLCFAs essential for membrane lipid composition and energy storage. It acts independently and does not form part of larger enzymatic complexes. The function of ELOVL7 aids in maintaining the integrity and functionality of cellular membranes influencing processes like cell signaling and membrane fluidity.

Pathways

ELOVL7 plays a significant role in the metabolism of lipids and fatty acids. This protein is an important component of the fatty acid elongation pathway. ELOVL7 interacts with enzymes like fatty acid synthase (FASN) within this pathway ensuring coordination in the synthesis and regulation of long-chain polyunsaturated fatty acids. This interlinked network demonstrates the protein's importance in maintaining lipid homeostasis.

Alterations in ELOVL7 function may contribute to conditions such as prostate cancer and neurodegenerative diseases. In prostate cancer dysregulated expression of ELOVL7 can affect lipid metabolism impacting cancer cell growth and survival. In neurodegenerative diseases ELOVL7 dysfunction affects membrane lipids critical for neuronal function and health. In these contexts ELOVL7's interaction with proteins like FASN influences disease progression and offers potential targets for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18 : 3(n-3) acyl-CoAs and C18 : 3(n-6)-CoAs. Also active toward C20 : 4-, C18 : 0-, C18 : 1-, C18 : 2- and C16 : 0-CoAs, and weakly toward C20 : 0-CoA. Little or no activity toward C22 : 0-, C24 : 0-, or C26 : 0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
See full target information ELOVL7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of proteomics 208:103482 PubMed31401171

2019

Integrated analysis of proteomics and metabolomics reveals the potential sex determination mechanism in Odontobutis potamophila.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wang,Wenxu Zhu,Hongyan Zhang,Xin Wen,Shaowu Yin,Yongyi Jia

Oncogene 37:710-721 PubMed29059155

2017

Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer.

Applications

WB

Species

Human

W Han,S Gao,D Barrett,M Ahmed,D Han,J A Macoska,H H He,C Cai
View all publications
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