Anti-ELYS antibody [2318C1a]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The ELYS protein also known as MEL-28 is a critical component of the nuclear pore complexes (NPCs) and plays an important role in nuclear envelope assembly. ELYS is approximately 240 kDa in mass and is expressed in various tissues with significant presence in dividing cells. ELYS facilitates the recruitment of nucleoporins to chromatin which is necessary for the formation of NPCs during cell division.

Biological function summary

ELYS protein associates as part of the nuclear pore complex. It functions as a nucleoporin that mediates the interaction between chromatin and NPC components. This interaction is essential for the reassembly of the nuclear envelope and the reestablishment of nucleocytoplasmic transport after mitosis. ELYS acts through its AT-hook domains allowing it to bind to chromatin.

Pathways

ELYS integrates into mechanisms involving nuclear envelope reformation and nucleocytoplasmic transport pathways. It associates with key proteins in these pathways including NUP107-160 complex establishing a functional connection between chromatin and the forming NPCs. ELYS is essential for the correct localization of other nucleoporins ensuring efficient nuclear pore assembly and nuclear transport processes.

Associated diseases and disorders

ELYS protein's dysfunction has links to cancer and neurological disorders. Defects in ELYS expression or mutations can impact correct NPC assembly affecting cellular homeostasis and leading to tumorigenesis. ELYS interaction with protein p53 plays an essential role in maintaining genomic stability which when disrupted can contribute to cancer development. Additionally changes in ELYS function have implications in neurodegenerative diseases where nuclear transport becomes compromised.