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AB153703

Anti-EML1 antibody - C-terminal

3

(1 Review)

|

(2 Publications)

Rabbit Polyclonal EML1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EML1 aa 550-850.

View Alternative Names

EMAP1, EMAPL, EMAPL1, EML1, Echinoderm microtubule-associated protein-like 1, EMAP-1, HuEMAP-1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-EML1 antibody - C-terminal (AB153703)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-EML1 antibody - C-terminal (AB153703)

Immunofluorescent analysis of methanol-fixed A549 cells labeling EML1 with ab153703 at 1/500 dilution. Lower image shows cells co-stained with Hoechst 33342.

Western blot - Anti-EML1 antibody - C-terminal (AB153703)
  • WB

Unknown

Western blot - Anti-EML1 antibody - C-terminal (AB153703)

7.5% SDS PAGE

All lanes:

Western blot - Anti-EML1 antibody - C-terminal (ab153703) at 1/1000 dilution

All lanes:

HepG2 cell lysate at 30 µg

Predicted band size: 90 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human EML1 aa 550-850. The exact immunogen used to generate this antibody is proprietary information.

O00423

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as EML1 or Echinoderm microtubule-associated protein-like 1 plays an important role in microtubule dynamics. EML1 assists in stabilizing and organizing microtubules which are cellular structures essential for cell shape division and intracellular transport. The protein has a molecular weight around 130 kDa. Researchers have found EML1 expression in various tissues including the brain where it contributes to the regulation of neuronal functions.
Biological function summary

EML1 interacts with microtubule networks supporting cellular architecture and processes such as mitosis and vesicle transport. This protein may integrate into larger protein complexes that modulate microtubule stability and dynamics. It also helps modulate intracellular signaling pathways which are critical for maintaining cellular homeostasis and development.

Pathways

EML1 participates in microtubule-associated pathways. It interacts with key proteins involved in these pathways such as tubulins to contribute to cell proliferation and differentiation. EML1 might engage in pathways like the MAPK signaling pathway where its microtubule-stabilizing function aids cell cycle regulation and growth factor signaling.

Researchers have linked EML1 mutations to brain malformations and developmental disorders such as microlissencephaly. Disruptions in its function may interfere with neuronal migration and cortical development contributing to these conditions. EML1 shows associations with proteins like LIS1 a dynein-interacting protein highlighting its potential role in neurodevelopmental diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
See full target information EML1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 38:1269-1282 PubMed36704943

2023

microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Zhu,Mo Chen,Wenwen Wang,Jianing Zhu,Huaxiang Wu

Neurobiology of disease 140:104836 PubMed32179177

2020

A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat.

Applications

Unspecified application

Species

Unspecified reactive species

Denise K Grosenbaugh,Suchitra Joshi,Mark P Fitzgerald,Kevin S Lee,Pravin K Wagley,Alexander F Koeppel,Stephen D Turner,Michael J McConnell,Howard P Goodkin
View all publications
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Product promise

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