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AB75190

Anti-EMR2 antibody

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(2 Publications)

Rabbit Polyclonal EMR2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRE2.

View Alternative Names

CD312, EMR2, ADGRE2, Adhesion G protein-coupled receptor E2, EGF-like module receptor 2, EGF-like module-containing mucin-like hormone receptor-like 2

1 Images
Western blot - Anti-EMR2 antibody (AB75190)
  • WB

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Western blot - Anti-EMR2 antibody (AB75190)

All lanes:

Western blot - Anti-EMR2 antibody (ab75190) at 1/500 dilution

Lane 1:

HeLa cell extract at 10 µg

Lane 2:

HeLa cell extract at 10 µg with immunising peptide

Predicted band size: 90 kDa

Observed band size: 91 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ADGRE2. The exact immunogen used to generate this antibody is proprietary information.

Q9UHX3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab75190 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EMR2 also known as epidermal growth factor-like module receptor 2 or CD312 is a member of the class B G protein-coupled receptor family. It is a large receptor with an approximate mass of 220 kDa. EMR2 is mainly expressed on leukocytes especially myeloid cells like monocytes and macrophages. EMR2 consists of an extensive extracellular domain that is involved in ligand binding influencing cell adhesion and signaling processes.
Biological function summary

EMR2 plays a role in the immune system by facilitating cell-cell interactions and guiding leukocyte trafficking. It forms part of a receptor complex that includes other G protein-coupled receptors. The receptor is essential in the regulation of inflammatory responses helping in the recognition and response to pathogens or tissue damage. EMR2's function contributes to the activation and migration of immune cells to sites of infection or injury.

Pathways

EMR2 interacts with intracellular signaling cascades such as the MAPK and PI3K pathways that manage cell proliferation survival and immune responses. Through these pathways EMR2 connects to proteins such as Akt and ERK facilitating downstream signaling mechanisms important for immune cell activation. The integration of EMR2 in these pathways positions it as an important player in cellular responses to external stimuli.

Aberrations in EMR2 function or expression relate to chronic inflammatory conditions and autoimmune disorders. Conditions such as rheumatoid arthritis and inflammatory bowel disease show altered EMR2 signaling indicating its role in the pathology of these diseases. In the context of these disorders other proteins like TNF-alpha and IL-6 often interact with EMR2 linking it to pro-inflammatory pathways and the exacerbation of disease symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed : 26841242).
See full target information ADGRE2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 22:173 PubMed40611130

2025

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Andjela Sekulic,Sarah M Herr,Kelly Mulfaul,Inga-Marie Pompös,Silvia Winkler,Carola Dietrich,Benedikt Obermayer,Robert F Mullins,Thomas Conrad,Peter F Zipfel,Florian Sennlaub,Christine Skerka,Olaf Strauß

Antioxidants (Basel, Switzerland) 14: PubMed40563263

2025

GG Modulates Mitochondrial Function and Antioxidant Responses in an Ethanol-Exposed In Vivo Model: Evidence of HIGD2A-Dependent OXPHOS Remodeling in the Liver.

Applications

Unspecified application

Species

Unspecified reactive species

Celia Salazar,Marlen Barreto,Alfredo Alfonso Adriasola-Carrasco,Francisca Carvajal,José Manuel Lerma-Cabrera,Lina María Ruiz
View all publications
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