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AB136102

Anti-Emx1 antibody

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(3 Publications)

Rabbit Polyclonal EMX1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Homeobox protein EMX1.

View Alternative Names

Homeobox protein EMX1, Empty spiracles homolog 1, Empty spiracles-like protein 1, EMX1

1 Images
Western blot - Anti-Emx1 antibody (AB136102)
  • WB

Unknown

Western blot - Anti-Emx1 antibody (AB136102)

All lanes:

Western blot - Anti-Emx1 antibody (ab136102) at 1/500 dilution

All lanes:

Jurkat cell extracts at 30 µg

Predicted band size: 28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Homeobox protein EMX1. The exact immunogen used to generate this antibody is proprietary information.

Q04741

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Alternative Products

Primary Antibodies

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Primary Antibodies

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Assay Kits

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Primary Antibodies

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Anti-GAD65 + GAD67 antibody [EPR19366]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab136102 was affinity purified from rabbit antiserum by immunogenic peptide affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Emx1 protein also known as Empty Spiracles Homeobox 1 acts as a transcription factor involved in the regulation of gene expression. Emx1 has a mass of approximately 29 kDa. It is expressed predominantly in the developing central nervous system particularly in the cerebral cortex and olfactory bulbs. During brain development Emx1 plays an important role in controlling the patterning and positioning of neurons.
Biological function summary

This transcription factor regulates the expression of various genes essential for brain structure organization and neuron differentiation. Emx1 often operates alongside other homeodomain proteins as part of transcriptional regulatory complexes to influence cortical development. These complexes guide the regional specification and morphological differentiation making Emx1 significant for organizing the structure of the brain.

Pathways

Emx1 is intricately involved in neuronal specification and differentiation pathways. It operates within the Wnt signaling pathway collaborating with proteins like Lhx2 to regulate neural progenitor cell fate and proliferation. The integration of Emx1 in these pathways ensures proper neuronal development and cerebral cortex maturation essential for brain function.

Mutations or dysregulation of Emx1 have associations with neurodevelopmental disorders such as autism spectrum disorder (ASD) and epilepsy. In these conditions Emx1's interaction with other transcription factors like Pax6 may contribute to abnormal neural development or cortical malformations highlighting its importance in maintaining normal brain function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
See full target information Homeobox protein EMX1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

eLife 11: PubMed35262486

2022

Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of , and mRNAs in developing mouse neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Kawssar Harb,Melanie Richter,Nagammal Neelagandan,Elia Magrinelli,Hend Harfoush,Katrin Kuechler,Melad Henis,Irm Hermanns-Borgmeyer,Froylan Calderon de Anda,Kent Duncan

Cell death & disease 12:515 PubMed34016958

2021

Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2.

Applications

Unspecified application

Species

Unspecified reactive species

Manuel Pedro Jimenez-García,Antonio Lucena-Cacace,Daniel Otero-Albiol,Amancio Carnero

Molecular cancer 14:86 PubMed25890345

2015

Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Ji,Yi Guo,Kapjun Kim,Peter McQueen,Samia Ghaffar,Alexander Christ,Carol Lin,Ramez Eskander,Xiaolin Zi,Bang H Hoang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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