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AB224343

Anti-Emx1 antibody

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(1 Publication)

Rabbit Polyclonal EMX1 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Homeobox protein EMX1 aa 50-200.

View Alternative Names

Homeobox protein EMX1, Empty spiracles homolog 1, Empty spiracles-like protein 1, EMX1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Emx1 antibody (AB224343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Emx1 antibody (AB224343)

Paraffin-embedded mouse E11 embryonic brain tissue stained for Emx1 with ab224343 (1/50) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Emx1 antibody (AB224343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Emx1 antibody (AB224343)

Paraffin-embedded human kidney tissue stained for Emx1 with ab224343 (1/50) in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Homeobox protein EMX1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q04741

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50.00000 - 1/200.00000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50.00000 - 1/200.00000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Emx1 protein also known as Empty Spiracles Homeobox 1 acts as a transcription factor involved in the regulation of gene expression. Emx1 has a mass of approximately 29 kDa. It is expressed predominantly in the developing central nervous system particularly in the cerebral cortex and olfactory bulbs. During brain development Emx1 plays an important role in controlling the patterning and positioning of neurons.
Biological function summary

This transcription factor regulates the expression of various genes essential for brain structure organization and neuron differentiation. Emx1 often operates alongside other homeodomain proteins as part of transcriptional regulatory complexes to influence cortical development. These complexes guide the regional specification and morphological differentiation making Emx1 significant for organizing the structure of the brain.

Pathways

Emx1 is intricately involved in neuronal specification and differentiation pathways. It operates within the Wnt signaling pathway collaborating with proteins like Lhx2 to regulate neural progenitor cell fate and proliferation. The integration of Emx1 in these pathways ensures proper neuronal development and cerebral cortex maturation essential for brain function.

Mutations or dysregulation of Emx1 have associations with neurodevelopmental disorders such as autism spectrum disorder (ASD) and epilepsy. In these conditions Emx1's interaction with other transcription factors like Pax6 may contribute to abnormal neural development or cortical malformations highlighting its importance in maintaining normal brain function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
See full target information Homeobox protein EMX1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 21: PubMed32106593

2020

BDNF Expression in Cortical GABAergic Interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Federico José Barreda Tomás,Paul Turko,Heike Heilmann,Thorsten Trimbuch,Yuchio Yanagawa,Imre Vida,Agnieszka Münster-Wandowski
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB136102

Anti-Emx1 antibody

primary-antibodies

emx1-antibody-ab136102

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