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AB171818

Anti-EMX2 antibody

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(3 Publications)

Mouse Polyclonal EMX2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EMX2.

View Alternative Names

Homeobox protein EMX2, Empty spiracles homolog 2, Empty spiracles-like protein 2, EMX2

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human EMX2.

Q04743

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Alternative Products

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Primary Antibodies

AB195045

Anti-PAX6 antibody [EPR15858]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EMX2 also known as Empty Spiracles Homeobox 2 functions as a homeobox transcription factor. This protein has a mass of approximately 33 kilodaltons. It is mainly expressed in the developing brain where it plays an important role in brain morphogenesis and neuronal development. EMX2 also presents in other tissues such as the kidney and reproductive organs where it contributes to organogenesis.
Biological function summary

The EMX2 protein influences developmental processes by regulating gene expression essential for cellular differentiation and tissue development. It does not belong to a larger complex but interacts with various transcription factors to exert its regulatory functions. EMX2 modulates important aspects of brain development guiding the patterning and regional specification within the cerebral cortex.

Pathways

EMX2 plays an influential role in the Wnt signaling pathway which is key to developmental processes like cell fate determination proliferation and migration. Additionally EMX2 is involved in the regulation of neural lineage specification through its interaction with other proteins such as PAX6. Together these proteins create a regulatory network that controls neural precursor cell proliferation and differentiation.

EMX2 has implications in neurological disorders. Abnormal expression or mutations in the EMX2 gene can contribute to developmental brain disorders such as schizencephaly which involves abnormal clefts or deep grooves in the cerebral hemispheres. The protein also links to cancer pathways notably in gliomas where dysregulation of EMX2 expression can affect tumor progression. Connections between EMX2 and proteins like GLI1 in the Glioma signaling pathway provide insights into its role in oncogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combination with OTX1/2 to specify cell fates in the developing central nervous system. In the inner ear, it controls the distribution of GPR156 at hair cell boundaries, and regulates the organization of stereociliary bundles in opposite orientations across the line of polarity reversal (LPR).
See full target information EMX2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 298:101548 PubMed34971707

2022

Exostosin glycosyltransferase 1 reduces porcine reproductive and respiratory syndrome virus infection through proteasomal degradation of nsp3 and nsp5.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxiao Zhang,Wenjuan Dong,Xun Wang,Zhenbang Zhu,Sheng He,Hui Zhang,Yaosheng Chen,Xiaohong Liu,Chunhe Guo

Reproductive biology and endocrinology : RB&E 19:187 PubMed34906165

2021

Increased METTL3-mediated mA methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure.

Applications

Unspecified application

Species

Unspecified reactive species

Pingping Xue,Wenbo Zhou,Wenqiang Fan,Jianya Jiang,Chengcai Kong,Wei Zhou,Jianmei Zhou,Xiaoyang Huang,Haiyan Yang,Qian Han,Bin Zhang,Lingyun Xu,Bin Yu,Li Chen

Cell death & disease 12:515 PubMed34016958

2021

Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2.

Applications

Unspecified application

Species

Unspecified reactive species

Manuel Pedro Jimenez-García,Antonio Lucena-Cacace,Daniel Otero-Albiol,Amancio Carnero
View all publications
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Product promise

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