Anti-ENDOD1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ENDOD1 also known as Endonuclease Domain Containing 1 is a protein with a molecular mass of approximately 63 kDa. This protein exhibits endonuclease activity which means it can cleave phosphodiester bonds within a nucleic acid chain. Researchers have observed its expression in various tissues with notably higher levels in the liver and pancreas. Through its endonuclease function ENDOD1 plays a role in nucleic acid metabolism participating in the processing and breakdown of RNA molecules.

Biological function summary

ENDOD1 is involved in maintaining cellular homeostasis by regulating RNA processing and turnover. It interacts within complex cellular environments contributing to the control of RNA stability. The protein does not operate in isolation but may associate with other nucleases and RNA-binding proteins to effectively mediate its functions. Its activity is important for the control of gene expression via RNA turnover and processing affecting cellular function and health.

Pathways

ENDOD1's role in RNA metabolism ensures its participation in the mRNA surveillance pathway. This pathway monitors the quality of mRNA and eliminates defective transcripts providing an essential quality control mechanism within the cell. ENDOD1 potentially interacts with proteins such as UPF1 a known participant in the nonsense-mediated decay pathway ensuring the degradation of faulty mRNA. Its involvement in these pathways highlights its importance for cellular quality control mechanisms.

Associated diseases and disorders

ENDOD1 has connections to disorders involving defective RNA metabolism including certain hepatic and digestive diseases. Abnormal expression or mutations in ENDOD1 may disrupt normal RNA processing contributing to disease states. Additionally ENDOD1 has been implicated in liver disease where its interaction with proteins involved in RNA degradation such as XRN1 might play a role in disease pathogenesis. Understanding ENDOD1's function helps in elucidating its role in the development of these diseases aiding in potential therapeutic targeting.