AB230018

Anti-Endomucin antibody

Name: Anti-Endomucin antibody (ab230018) | Abcam
Brand: Abcam Limited
SKU: AB230018
Price: 510 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal Endomucin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EMCN aa 1-150.

View Alternative Names

EMCN2, MUC14, EMCN, Endomucin, Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endomucin antibody (AB230018)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endomucin antibody (AB230018)

Paraffin-embedded human skeletal muscle tissue stained for endomucin using ab230018 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endomucin antibody (AB230018)

Paraffin-embedded human kidney tissue stained for endomucin using ab230018 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human EMCN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q9ULC0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endomucin also known as EMCN is a glycoprotein with a molecular mass of approximately 75 kDa. As part of the endothelial glycocalyx endomucin is expressed predominantly in endothelial cells lining blood vessels. This protein is involved in the prevention of leukocyte-endothelial cell adhesion and regulates cell surface exposure of adhesion molecules. Endomucin’s expression can be detected in tissues with high vascularization such as the heart and lungs.

Biological function summary

Endomucin modulates the vascular permeability and the anti-inflammatory responses of endothelial tissues. It interacts with other proteins within the endothelial cell surface matrix forming a complex with proteoglycans and glycoproteins. Through these interactions endomucin plays an important role in maintaining endothelial barrier integrity and vascular homeostasis contributing to the regulation of angiogenesis and endothelial cell function.

Pathways

Endomucin engages in the regulation of the inflammatory and angiogenic pathways. It modulates the Notch signaling pathway which is key for maintaining vascular development and function. Additionally interactions with components like vascular endothelial growth factor (VEGF) highlight its involvement in angiogenic processes closely linking endomucin to pathways that govern cell proliferation and migration in endothelial tissues.

Endomucin is significantly linked to inflammatory diseases such as atherosclerosis and cardiovascular abnormalities. In these contexts it interacts with adhesion molecules such as E-selectin influencing the progression of inflammation and vascular inflammation. Altered expression or dysfunction of endomucin could potentially contribute to these diseases underlining its relevance in vascular pathophysiology and endothelial health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

See full target information EMCN

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 15: PubMed36678216

2023

Differential Regulation of Glucosylceramide Synthesis and Efflux by Golgi and Plasma Membrane Bound ABCC10.

Applications

Unspecified application

Species

Unspecified reactive species

Jahangir Iqbal,Abeer Al Otaibi,Sindiyan Alshaikh Mubarak,Ali Alqarni,Ahmed Bakillah

Cell death & disease 11:457 PubMed32541667

2020

Snail promotes the generation of vascular endothelium by breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenyu Chang,Yanan Zhang,Jie Liu,Yiqiong Zheng,Huayue Li,Yanjun Kong,Pengyun Li,Haiwen Peng,Yajiao Shi,Bo Cao,Fang Ran,Yingjie Chen,Yuhua Song,Qinong Ye,Lihua Ding

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Endomucin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endomucin antibody (AB230018)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endomucin antibody (AB230018)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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