Anti-Endomucin antibody [V.7C7.1]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Endomucin also known as EMCN is a glycoprotein with a molecular mass of approximately 75 kDa. As part of the endothelial glycocalyx endomucin is expressed predominantly in endothelial cells lining blood vessels. This protein is involved in the prevention of leukocyte-endothelial cell adhesion and regulates cell surface exposure of adhesion molecules. Endomucin’s expression can be detected in tissues with high vascularization such as the heart and lungs.

Biological function summary

Endomucin modulates the vascular permeability and the anti-inflammatory responses of endothelial tissues. It interacts with other proteins within the endothelial cell surface matrix forming a complex with proteoglycans and glycoproteins. Through these interactions endomucin plays an important role in maintaining endothelial barrier integrity and vascular homeostasis contributing to the regulation of angiogenesis and endothelial cell function.

Pathways

Endomucin engages in the regulation of the inflammatory and angiogenic pathways. It modulates the Notch signaling pathway which is key for maintaining vascular development and function. Additionally interactions with components like vascular endothelial growth factor (VEGF) highlight its involvement in angiogenic processes closely linking endomucin to pathways that govern cell proliferation and migration in endothelial tissues.

Associated diseases and disorders

Endomucin is significantly linked to inflammatory diseases such as atherosclerosis and cardiovascular abnormalities. In these contexts it interacts with adhesion molecules such as E-selectin influencing the progression of inflammation and vascular inflammation. Altered expression or dysfunction of endomucin could potentially contribute to these diseases underlining its relevance in vascular pathophysiology and endothelial health.