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AB106100

Anti-Endomucin antibody [V.7C7.1]

5

(9 Reviews)

|

(82 Publications)

Anti-Endomucin antibody [V.7C7.1] (ab106100) is a rat monoclonal antibody detecting Endomucin in Western Blot, Flow Cytometry, IP, IHC-P, IHC-Fr, IHC- Wmt, ICC/IF. Suitable for Mouse.

- Over 50 publications

View Alternative Names

EMCN2, MUC14, EMCN, Endomucin, Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Endomucin antibody [V.7C7.1] (AB106100)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Endomucin antibody [V.7C7.1] (AB106100)

Immuno fluorescence staining of bEND3 cells with ab106100 at a concentration of 1 μg/ml.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

V.7C7.1

Isotype

IgG2a

Carrier free

No

Reacts with

Mouse

Applications

WB, IHC-P, IP, IHC-Fr, IHC - Wmt, Flow Cyt, ICC/IF

applications

Immunogen

Recombinant Protein within Mouse Emcn. The exact immunogen used to generate this antibody is proprietary information.

Q9R0H2

Reactivity data

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Product details

What is this antibody validated in?
Anti-Endomucin antibody [V.7C7.1] (ab106100) is a rat monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunohistochemistry (IHC - Wmt), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples.

Trusted by the scientific community
Anti-Endomucin [V.7C7.1] (ab106100) was first used in a scientific publication in 2011 and has been cited over 50 times in peer-reviewed journals.

Reviewed by scientists
Anti-Endomucin [V.7C7.1] (ab106100) has over 5 independent reviews from customers.

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
0.2 µm filtered solution
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endomucin also known as EMCN is a glycoprotein with a molecular mass of approximately 75 kDa. As part of the endothelial glycocalyx endomucin is expressed predominantly in endothelial cells lining blood vessels. This protein is involved in the prevention of leukocyte-endothelial cell adhesion and regulates cell surface exposure of adhesion molecules. Endomucin’s expression can be detected in tissues with high vascularization such as the heart and lungs.
Biological function summary

Endomucin modulates the vascular permeability and the anti-inflammatory responses of endothelial tissues. It interacts with other proteins within the endothelial cell surface matrix forming a complex with proteoglycans and glycoproteins. Through these interactions endomucin plays an important role in maintaining endothelial barrier integrity and vascular homeostasis contributing to the regulation of angiogenesis and endothelial cell function.

Pathways

Endomucin engages in the regulation of the inflammatory and angiogenic pathways. It modulates the Notch signaling pathway which is key for maintaining vascular development and function. Additionally interactions with components like vascular endothelial growth factor (VEGF) highlight its involvement in angiogenic processes closely linking endomucin to pathways that govern cell proliferation and migration in endothelial tissues.

Endomucin is significantly linked to inflammatory diseases such as atherosclerosis and cardiovascular abnormalities. In these contexts it interacts with adhesion molecules such as E-selectin influencing the progression of inflammation and vascular inflammation. Altered expression or dysfunction of endomucin could potentially contribute to these diseases underlining its relevance in vascular pathophysiology and endothelial health.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
See full target information EMCN

Publications (82)

Recent publications for all applications. Explore the full list and refine your search

Drug design, development and therapy 19:2173-2188 PubMed40160965

2025

MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Ding,Weidong Zhang,Ting Liu,Xing Rong,Yajun Cui,Lingxiao Meng,Luxu Wang,Bo Liu,Minqi Li

PLoS biology 23:e3003003 PubMed39874373

2025

Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowen Chen,Joanna Tober,Martin Dominguez,Alan T Tang,Jenna Bockman,Jisheng Yang,Sneha Mani,Chin Nien Lee,Mei Chen,Triloshan Thillaikumaran,Patricia Mericko-Ishizuka,Monica Mainigi,Nancy A Speck,Mark L Kahn

The Journal of clinical investigation 135: PubMed39621585

2024

Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Ratnakar Tiwari,Rajni Sharma,Ganeshkumar Rajendran,Gabriella S Borkowski,Si Young An,Michael Schonfeld,James O'Sullivan,Matthew J Schipma,Yalu Zhou,Guillaume Courbon,Benjamin R Thomson,Valentin David,Susan E Quaggin,Edward B Thorp,Navdeep S Chandel,Pinelopi P Kapitsinou

Pulmonary circulation 14:e70013 PubMed39582775

2024

High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Hong,Guozhou You,Zhongming Luo,Mingxiang Zhang,Jian Chen

Aging cell 24:e14374 PubMed39411913

2024

Aβ -induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Weidong Zhang,Fan Ding,Xing Rong,Qinghua Ren,Tomoka Hasegawa,Hongrui Liu,Minqi Li

Cellular and molecular life sciences : CMLS 81:344 PubMed39133273

2024

Exosomes derived from BMSCs in osteogenic differentiation promote type H blood vessel angiogenesis through miR-150-5p mediated metabolic reprogramming of endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Wu,Chengchao Song,Guanqi Zhen,Qin Jin,Wei Li,Xiongjie Liang,Wenbo Xu,Wenhui Guo,Yang Yang,Wei Dong,Anlong Jiang,Pengyu Kong,Jinglong Yan

Diabetes, obesity & metabolism 26:3880-3896 PubMed38951947

2024

Neuregulin4-ErbB4 signalling pathway is driven by electroacupuncture stimulation to remodel brown adipose tissue innervation.

Applications

Unspecified application

Species

Unspecified reactive species

Ziwei Yu,Ting Zhang,Xingyu Yang,Bin Xu,Zhi Yu,Li An,Tiancheng Xu,Xinyue Jing,Yaling Wang,Mengjiang Lu

JHEP reports : innovation in hepatology 6:101023 PubMed38681862

2024

Liver specification of human iPSC-derived endothelial cells transplanted into mouse liver.

Applications

Unspecified application

Species

Unspecified reactive species

Kiryu K Yap,Jan Schröder,Yi-Wen Gerrand,Aleksandar Dobric,Anne M Kong,Adrian M Fox,Brett Knowles,Simon W Banting,Andrew G Elefanty,Eduoard G Stanley,George C Yeoh,Glen P Lockwood,Victoria C Cogger,Wayne A Morrison,Jose M Polo,Geraldine M Mitchell

Bone research 12:24 PubMed38594260

2024

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization.

Applications

Unspecified application

Species

Unspecified reactive species

Longqing Wang,Wenhao Jiang,Siyuan Zhao,Dong Xie,Qing Chen,Qi Zhao,Hao Wu,Jian Luo,Lili Yang

Nature communications 15:2939 PubMed38580630

2024

Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yonggang Fan,Weixin Zhang,Xiusheng Huang,Mingzhe Fan,Chenhao Shi,Lantian Zhao,Guofu Pi,Huafeng Zhang,Shuangfei Ni
View all publications

Product promise

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