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AB153867

Anti-Endothelin 2/ET-2 antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal Endothelin 2/ET-2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EDN2 aa 1 to C-terminus.

View Alternative Names

Endothelin-2, ET-2, Preproendothelin-2, PPET2, EDN2

1 Images
Western blot - Anti-Endothelin 2/ET-2 antibody (AB153867)
  • WB

Unknown

Western blot - Anti-Endothelin 2/ET-2 antibody (AB153867)

12% SDS PAGE

All lanes:

Western blot - Anti-Endothelin 2/ET-2 antibody (ab153867) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 20 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human EDN2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P20800

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Alternative Products

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AB197763

Anti-Endothelin 2/ET-2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endothelin 2/ET-2 antibody (AB197763)

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endothelin 2 (ET-2) also known as EDN2 is a small peptide with a molecular mass of approximately 2.5 kDa. It belongs to the endothelin family of peptides which includes three isopeptides: ET-1 ET-2 and ET-3. ET-2 expresses in various tissues with notable abundance in the kidney intestines and ovary. The peptide functions by binding to endothelin receptors mainly ETA and ETB on the surface of cells facilitating a range of physiological responses.
Biological function summary

Endothelin 2 modulates vasoconstriction and plays a role in blood pressure regulation. ET-2 functions in tandem with endothelin receptors forming part of a complex signaling network. It influences processes like smooth muscle contraction and cellular proliferation. Additionally ET-2 involves itself in reproductive function particularly within female reproductive tissues affecting ovarian physiology.

Pathways

Endothelin 2 integrates into the endothelin signaling pathway which is pivotal for vascular tone regulation. It interacts with other critical components such as ET-1 within this pathway. ET-2 also relates to the MAPK/ERK pathway which governs cell growth and differentiation. Through these pathways ET-2 coordinates tissue responses to various physiological stimuli often in conjunction with proteins like endothelin receptors and MAPKs.

Endothelin 2 shows a link to conditions such as hypertension and polycystic ovary syndrome (PCOS). Aberrant ET-2 expression can contribute to vascular dysfunction in hypertension. In PCOS ET-2 may regulate ovarian stroma and granulosa cell function with potential connections to proteins like follicle-stimulating hormone (FSH) highlighting its importance in reproductive pathophysiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endothelins are endothelium-derived vasoconstrictor peptides.
See full target information EDN2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 5:765-776 PubMed37198474

2023

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Owen S Skinner,Joan Blanco-Fernández,Russell P Goodman,Akinori Kawakami,Hongying Shen,Lajos V Kemény,Lena Joesch-Cohen,Matthew G Rees,Jennifer A Roth,David E Fisher,Vamsi K Mootha,Alexis A Jourdain
View all publications
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Product promise

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