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AB172085

Anti-Enkephalin/ENK antibody

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(1 Publication)

Mouse Polyclonal Enkephalin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PENK.

View Alternative Names

Proenkephalin-A, PENK

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PENK.

P01210

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Complementary Products

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AB17934

Anti-Mu Opioid Receptor antibody

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Primary Antibodies

AB283514

Anti-Proenkephalin-B antibody [EPR24508-78] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proenkephalin-B antibody [EPR24508-78] - BSA and Azide free (AB283514)

  • 0
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Primary Antibodies

AB113533

Anti-Kappa Opioid Receptor antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kappa Opioid Receptor antibody (AB113533)

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Primary Antibodies

AB111912

Anti-Somatostatin 28 antibody [EPR3359(2)]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin 28 antibody [EPR3359(2)] (AB111912)

  • 5
  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Enkephalin also known as ENK is a pentapeptide involved in regulating pain and emotion. It exists in two main forms: Leu-enkephalin and Met-enkephalin with molecular masses of 555.62 g/mol and 573.66 g/mol respectively. ENK peptides are primarily expressed in the central nervous system particularly in regions such as the thalamus hypothalamus and basal ganglia. They bind to opioid receptors especially the delta and mu receptors to modulate neurotransmission.
Biological function summary

Enkephalins play an important role in modulating pain perception and stress response. They do not operate alone but rather as components of a dynamic system involving other endogenous opioids and neuromodulators. Enkephalins participate in analgesic effects by binding to opioid receptors inhibiting neurotransmitter release and reducing neuronal excitability. Their interaction with other neurotransmitters including serotonin and norepinephrine suggests a broader role in emotional regulation and mood balance.

Pathways

Enkephalins engage in the opioid signaling pathway which influences pain and emotional states. This pathway interacts closely with the dopamine pathway where enkephalins modulate dopamine neurotransmission in areas related to reward and motivation. Other proteins such as the opioid receptors and prodynorphin play essential roles alongside enkephalins in these pathways contributing to complex interactions affecting mood and behavior.

Enkephalins relate to addiction and chronic pain conditions. They influence the rewarding effects of addictive substances interacting with dopamine receptor systems that can lead to dependency. Furthermore their involvement in pain pathways makes them relevant to the understanding and treatment of chronic pain disorders. Proteins like dynorphin another opioid peptide also link to these conditions often interacting with enkephalins to modulate pain and emotional response.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Met-enkephalin. Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.. Leu-enkephalin. Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.. Met-enkephalin-Arg-Phe. Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.. PENK(114-133). Increases glutamate release in the striatum and decreases GABA concentration in the striatum.. PENK(237-258). Increases glutamate release in the striatum.
See full target information PENK
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The journal of gene medicine 23:e3332 PubMed33783904

2021

Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jianzhuang Gong,Chenxu Du,Nai Sun,Xingguo Xiao,Huili Wu
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Product promise

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