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AB197391

Anti-ENPP5 antibody

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(1 Publication)

Rabbit Polyclonal ENPP5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ENPP5.

View Alternative Names

UNQ550/PRO1107, ENPP5, Ectonucleotide pyrophosphatase/phosphodiesterase family member 5, E-NPP 5, NPP-5

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENPP5 antibody (AB197391)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENPP5 antibody (AB197391)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue labeling ENPP5 with ab197391 at a 1/40 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENPP5 antibody (AB197391)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENPP5 antibody (AB197391)

Immunohistochemical analysis of paraffin-embedded human tonsil cancer tissue labeling ENPP5 with ab197391 at a 1/40 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ENPP5. The exact immunogen used to generate this antibody is proprietary information.

Q9UJA9

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ENPP5 also known as Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 5 is an enzyme that belongs to the ENPP family. It plays a role in the hydrolysis of phosphodiester bonds although specific substrates for ENPP5 remain less well-defined compared to other ENPPs. This protein has a molecular weight of approximately 49 kDa. ENPP5 is mainly expressed in tissues such as the brain and the kidneys suggesting it holds specialized functions in these areas.
Biological function summary

Researchers propose that ENPP5 contributes to nucleotide metabolism and signaling processes. Although ENPP5 is not directly part of a larger protein complex it functions alongside similar enzymes sharing common substrates and physiological roles. By maintaining balance in the extracellular nucleotide levels ENPP5 can influence processes such as cellular signaling potentially affecting cell growth and differentiation in its primary tissues.

Pathways

ENPP5 activity relates to purine metabolism and the signal transduction pathways that involve nucleotides. One primary pathway where it plays a role is the nucleotide catabolic process interacting indirectly with proteins such as ENPP1 and ENPP2 that manage pyrophosphate and phospholipid metabolism. ENPP5 by breaking down nucleotides influences signal transduction pathways like the P2Y receptor-mediated pathways which are important for various physiological functions.

ENPP5 has connections with conditions involving defective nucleotide metabolism or signaling imbalances. Researchers suggest possible links to neurological disorders due to its expression in the brain though exact implications require further study. ENPP5 alongside proteins like ENPP1 may show involvement in pathologies characterized by abnormal ectonucleotide levels. However more research is essential to establish clear associations with specific diseases such as neurodegenerative disorders or renal pathologies.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication.
See full target information ENPP5

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Life metabolism 1:242-257 PubMed39872077

2022

A multi-omic landscape of steatosis-to-NASH progression.

Applications

Unspecified application

Species

Unspecified reactive species

Liping Xiang,Xiaoyan Li,Yunchen Luo,Bing Zhou,Yuejun Liu,Yao Li,Duojiao Wu,Lijing Jia,Pei-Wu Zhu,Ming-Hua Zheng,Hua Wang,Yan Lu
View all publications

Product promise

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