AB36367

Anti-Enterovirus 71 antibody [10F0]

Name: Anti-Enterovirus 71 antibody [10F0] (ab36367) | Abcam
Brand: Abcam Limited
SKU: AB36367

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(25 Publications)

Mouse Monoclonal Enterovirus 71 antibody. Suitable for FuncS (Neut/Block), ICC/IF and reacts with Enterovirus A71 samples. Cited in 25 publications. Immunogen corresponding to Virus preparation containing Enterovirus 71 protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

10F0

Isotype

IgG1

Carrier free

Reacts with

Enterovirus A71

Applications

FuncS (Neut/Block), ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Enterovirus A71": { "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "1/14", "FuncSNeutBlock-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/500 - 1/2000", "ICCIF-species-notes": "<p>Fix with cold acetone for 10 minutes. Dilute antibody in PBS (pH 7.5 to pH 8.0) with 1% BSA.</p>" } } }

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

Constituents: Ascites

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Enterovirus 71 (EV71) also known as enteroviral VP1 is a significant member of the enterovirus genus. Mechanically EV71 is a small RNA virus with a protein capsid that is important for viral replication and cell infection. The virus is around 30 nm in diameter and the capsid proteins including VP1 play an important role in its structure and function. EV71 is primarily expressed in human tissues that include the gastrointestinal tract and central nervous system. The VP1 protein is essential for receptor recognition and mediates the attachment of the virus to host cells facilitating the entry of the viral RNA into the host cell.

Biological function summary

EV71 infects host cells and hijacks the cellular machinery to replicate itself causing cytopathic effects. The VP1 protein is a critical part of the viral capsid complex and interacts with host cell receptors initiating infection. This process causes the host cell to undergo apoptosis and releases new viral particles perpetuating the infection cycle. EV71 plays a substantial role in disrupting host cellular processes which then leads to notable clinical symptoms.

Pathways

EV71 interacts with host cellular pathways involved in viral replication and immune response. Specifically the virus can affect the signal transduction pathways important for the host's antiviral defenses such as the type I interferon pathway. This interaction allows the virus to evade the immune system temporarily. Additionally EV71 affects the proteasome pathway that includes proteins related to antigen presentation which is essential for an adequate immune response by the host.

EV71 is most notably associated with hand foot and mouth disease and can cause severe neurological complications like encephalitis. The virus can affect young children severely and outbreaks have led to significant health concerns in various regions. EV71 interacts with proteins involved in immune surveillance such as those within the interferon response pathways which play a critical role in the pathogenesis of its related diseases. Understanding this interaction is important for developing therapeutic monoclonal antibodies such as mab979 that can target EV71 infections.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Enterovirus 71

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Publications (25)

Recent publications for all applications. Explore the full list and refine your search

BMC microbiology 25:53 PubMed39881250

2025

6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Qiao You,Jing Wu,Ruining Lyu,Yurong Cai,Na Jiang,Ye Liu,Fang Zhang,Yating He,Deyan Chen,Zhiwei Wu

EMBO molecular medicine 16:2516-2538 PubMed39261649

2024

Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Deyan Chen,Jing Wu,Fang Zhang,Ruining Lyu,Qiao You,Yajie Qian,Yurong Cai,Xiaoyan Tian,Hongji Tao,Yating He,Waqas Nawaz,Zhiwei Wu

Frontiers in cellular and infection microbiology 14:1340075 PubMed38628549

2024

Enterovirus A71 infection-induced dry eye-like symptoms by damaging the lacrimal glands.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Zhou,Taige Chen,Qiao You,Deyan Chen,Lifei Liu,Kai Hu

Journal of medical virology 95:e28915 PubMed37417384

2023

Enterovirus 71 enters human brain microvascular endothelial cells through an ARF6-mediated endocytic pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yongzhe Zhu,Xiaohang Wang,Zhiwei He,Ping Zhao,Hao Ren,Zhongtian Qi

Virus research 330:199108 PubMed37024058

2023

Targeting HDAC11 activity by FT895 restricts EV71 replication.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Xie,Enhui Yang,Chaoyong Wang,Chunyan Peng,Lianfu Ji

Proteomics 23:e2200362 PubMed36254857

2022

Proteomic and metabonomic analysis uncovering Enterovirus A71 reprogramming host cell metabolic pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Huichun Shi,Siyuan Liu,Zhimi Tan,Lin Yin,Liyan Zeng,Tiefu Liu,Shuye Zhang,Lijun Zhang

Journal of virology 96:e0054221 PubMed35319229

2022

3,4-Dicaffeoylquinic Acid from the Medicinal Plant Disrupts the Interaction Between the Five-Fold Axis of Enterovirus A-71 and the Heparan Sulfate Receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Chung-Fan Hsieh,Yu-Li Chen,Guan-Hua Lin,Yoke Fun Chan,Pei-Wen Hsieh,Jim-Tong Horng

Frontiers in microbiology 12:762869 PubMed34992585

2021

Enterovirus A71 2B Inhibits Interferon-Activated JAK/STAT Signaling by Inducing Caspase-3-Dependent Karyopherin-α1 Degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Menghuai Sun,Qian Lin,Chunyang Wang,Jiao Xing,Kunlong Yan,Zhifeng Liu,Yu Jin,Carol J Cardona,Zheng Xing

PLoS pathogens 17:e1010018 PubMed34695168

2021

Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Soo Jin Park,Uram Jin,Sang Myun Park

Frontiers in cellular and infection microbiology 11:725392 PubMed34485180

2021

DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Zhang,Min Cheng,Bingxin Liu,Meng Yuan,Deyan Chen,Yujiong Wang,Zhiwei Wu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Enterovirus 71 antibody [10F0]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (25)

Product promise