Anti-Enterovirus 71 VP1 antibody [HL1928]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Enterovirus 71 (EV71) also known as enteroviral VP1 is a significant member of the enterovirus genus. Mechanically EV71 is a small RNA virus with a protein capsid that is important for viral replication and cell infection. The virus is around 30 nm in diameter and the capsid proteins including VP1 play an important role in its structure and function. EV71 is primarily expressed in human tissues that include the gastrointestinal tract and central nervous system. The VP1 protein is essential for receptor recognition and mediates the attachment of the virus to host cells facilitating the entry of the viral RNA into the host cell.

Biological function summary

EV71 infects host cells and hijacks the cellular machinery to replicate itself causing cytopathic effects. The VP1 protein is a critical part of the viral capsid complex and interacts with host cell receptors initiating infection. This process causes the host cell to undergo apoptosis and releases new viral particles perpetuating the infection cycle. EV71 plays a substantial role in disrupting host cellular processes which then leads to notable clinical symptoms.

Pathways

EV71 interacts with host cellular pathways involved in viral replication and immune response. Specifically the virus can affect the signal transduction pathways important for the host's antiviral defenses such as the type I interferon pathway. This interaction allows the virus to evade the immune system temporarily. Additionally EV71 affects the proteasome pathway that includes proteins related to antigen presentation which is essential for an adequate immune response by the host.

Associated diseases and disorders

EV71 is most notably associated with hand foot and mouth disease and can cause severe neurological complications like encephalitis. The virus can affect young children severely and outbreaks have led to significant health concerns in various regions. EV71 interacts with proteins involved in immune surveillance such as those within the interferon response pathways which play a critical role in the pathogenesis of its related diseases. Understanding this interaction is important for developing therapeutic monoclonal antibodies such as mab979 that can target EV71 infections.