Anti-Enterovirus D68 VP1 antibody [HL1997]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Enterovirus VP1 also known as viral protein 1 is a structural protein of the enterovirus capsid. It has a mass of approximately 30 kilodaltons and plays an important role in virus assembly and host cell interaction. The protein is expressed on the viral surface and it is responsible for initial binding to the host cell receptors. This interaction facilitates the entry of the virus into cells initiating the infectious cycle. Enterovirus VP1 is highly conserved among different enterovirus serotypes which allows it to serve as a target for diagnostics and therapeutic interventions.

Biological function summary

This protein enables the structural integrity and infectivity of the virus. Enterovirus VP1 is a part of the viral capsid a protein complex that also includes VP2 VP3 and VP4. These proteins collectively protect the viral RNA genome and are involved in mediating interactions with the host immune system. The conformational structure of VP1 is recognized by neutralizing antibodies making it a focus point for vaccine development and antiviral drugs. Its expression and conformation can influence the antigenicity and serotype specificity of enteroviruses.

Pathways

Several actions revolving around host-pathogen interactions involve Enterovirus VP1. It plays a pivotal role in the cell entry mechanism through endocytic pathways. VP1 interacts with proteins such as ICAM-1 or PSGL-1 which serves as receptors in the early stages of viral pathogenesis. Additionally during viral uncoating and RNA release VP1 undergoes structural rearrangements that are essential for subsequent steps in the viral lifecycle and involve complex pathways like the host cell defense mechanism.

Associated diseases and disorders

Alterations in Enterovirus VP1 are significant in the context of ailments like hand foot and mouth disease and viral myocarditis. The protein's sequence variations can influence disease severity and transmission. Furthermore correlations have been established between the structural aspects of VP1 and host proteins involved in disease manifestation such as cellular kinases influencing viral replication. This protein's interactions and mutations contribute to the pathogenicity and epidemiology of enterovirus-related diseases.