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AB150503

Anti-ENTPD2 antibody

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(1 Publication)

Rabbit Polyclonal ENTPD2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ENTPD2.

View Alternative Names

CD39L1, ENTPD2, Ectonucleoside triphosphate diphosphohydrolase 2, NTPDase 2, CD39 antigen-like 1, Ecto-ATP diphosphohydrolase 2, Ecto-ATPDase 2, Ecto-ATPase 2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENTPD2 antibody (AB150503)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENTPD2 antibody (AB150503)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cortex labelling ENTPD2 with ab150503 at 2.5 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ENTPD2. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5L3

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ENTPD2 also known as ectonucleoside triphosphate diphosphohydrolase 2 or CD39L1 functions as an enzyme that hydrolyzes nucleoside triphosphates and diphosphates into their respective monophosphates while releasing inorganic phosphate. It has a molecular mass of approximately 61 kDa. This protein is expressed in many tissues with a notable presence in the human liver placenta and pancreas. Its expression on endothelial and epithelial cells suggests active involvement in vascular and surface barrier systems.
Biological function summary

ENTPD2 participates in the regulation of extracellular nucleotide levels which influences various physiological processes. It works as part of the nucleoside triphosphate diphosphohydrolase family that controls purinergic signaling by degrading high-energy nucleotides. This regulation affects cellular activities such as proliferation and apoptosis. Its role is critical in modulating the availability of nucleotides for homeostatic and stress responses in the body.

Pathways

ENTPD2 is involved in purinergic signaling and ATP metabolism pathways. These pathways are significant in maintaining cellular energy balance and facilitating communication between cells through signaling molecules like ATP and ADP. ENTPD2 has a functional interplay with other proteins like ENTPD1 and adenosine deaminase during these processes ensuring tight regulation of extracellular nucleotides and their products.

ENTPD2 shows associations with cancer particularly hepatocellular carcinoma and inflammatory diseases. It is an important player in cancer due to its ability to modulate the tumor microenvironment through purinergic signaling influencing tumor growth and metastasis. Inflammatory responses also connect to ENTPD2 activity where altered expression can contribute to chronic inflammation conditions. The protein's interaction with CD39 another member of the ectonucleotidase family highlights its important role in these pathological contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
See full target information ENTPD2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 8:517 PubMed28894087

2017

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

David Kung-Chun Chiu,Aki Pui-Wah Tse,Iris Ming-Jing Xu,Jane Di Cui,Robin Kit-Ho Lai,Lynna Lan Li,Hui-Yu Koh,Felice Ho-Ching Tsang,Larry Lai Wei,Chun-Ming Wong,Irene Oi-Lin Ng,Carmen Chak-Lui Wong
View all publications
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Product promise

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