Anti-ENTPD2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ENTPD2 also known as ectonucleoside triphosphate diphosphohydrolase 2 or CD39L1 functions as an enzyme that hydrolyzes nucleoside triphosphates and diphosphates into their respective monophosphates while releasing inorganic phosphate. It has a molecular mass of approximately 61 kDa. This protein is expressed in many tissues with a notable presence in the human liver placenta and pancreas. Its expression on endothelial and epithelial cells suggests active involvement in vascular and surface barrier systems.

Biological function summary

ENTPD2 participates in the regulation of extracellular nucleotide levels which influences various physiological processes. It works as part of the nucleoside triphosphate diphosphohydrolase family that controls purinergic signaling by degrading high-energy nucleotides. This regulation affects cellular activities such as proliferation and apoptosis. Its role is critical in modulating the availability of nucleotides for homeostatic and stress responses in the body.

Pathways

ENTPD2 is involved in purinergic signaling and ATP metabolism pathways. These pathways are significant in maintaining cellular energy balance and facilitating communication between cells through signaling molecules like ATP and ADP. ENTPD2 has a functional interplay with other proteins like ENTPD1 and adenosine deaminase during these processes ensuring tight regulation of extracellular nucleotides and their products.

Associated diseases and disorders

ENTPD2 shows associations with cancer particularly hepatocellular carcinoma and inflammatory diseases. It is an important player in cancer due to its ability to modulate the tumor microenvironment through purinergic signaling influencing tumor growth and metastasis. Inflammatory responses also connect to ENTPD2 activity where altered expression can contribute to chronic inflammation conditions. The protein's interaction with CD39 another member of the ectonucleotidase family highlights its important role in these pathological contexts.