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AB96335

Anti-ENTPD3 antibody

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(2 Publications)

Rabbit Polyclonal ENTPD3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ENTPD3 aa 200-450.

View Alternative Names

CD39L3, ENTPD3, Ectonucleoside triphosphate diphosphohydrolase 3, NTPDase 3, CD39 antigen-like 3, Ecto-ATP diphosphohydrolase 3, Ecto-apyrase 3, HB6, Ecto-ATPDase 3, Ecto-ATPase 3

1 Images
Western blot - Anti-ENTPD3 antibody (AB96335)
  • WB

Unknown

Western blot - Anti-ENTPD3 antibody (AB96335)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-ENTPD3 antibody (ab96335) at 1/2000 dilution

All lanes:

MOLT4 cell lysate at 30 µg

Predicted band size: 59 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ENTPD3 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.

O75355

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ENTPD3 also known as NTPDase 3 an enzyme present on the cell surface functions in nucleotide metabolism by hydrolyzing ATP and ADP to AMP and inorganic phosphate. It is a member of the ectonucleoside triphosphate diphosphohydrolase family and encoded by the ENTPD3 gene. This protein has an approximate mass of 65 kDa. Expression of ENTPD3 is found in various tissues notably in the brain and pancreas contributing to its role in nucleotide regulation in these areas.
Biological function summary

ENTPD3 serves a role in the control of extracellular nucleotide levels affecting purinergic signaling. This enzyme operates as part of the broader purinergic signaling complex and plays a role in modulating the availability of nucleotides for signal transduction. ENTPD3's activity modulates neurotransmission and vascular function highlighting its importance in these biological processes within specific tissues like the nervous system and endothelial cells.

Pathways

ENTPD3 participates in the purinergic signaling pathway where it regulates extracellular levels of nucleotides influencing signaling events related to cellular communication and response. This pathway interacts closely with other proteins like P2X and P2Y receptors which are also integral to nucleotides' function as signaling molecules. ENTPD3's role in this pathway highlights its involvement in maintaining homeostasis in cellular environments.

ENTPD3 links to conditions such as neuropathic pain and diabetes. Dysregulation of purinergic signaling where ENTPD3 is an important player can contribute to abnormal cell signaling and inflammation which has been noted in neuropathic pain. Moreover its expression in the pancreas suggests a connection to insulin regulation and consequently diabetes. Interaction with other proteins such as those in the insulin signaling pathway frames ENTPD3 as a potential target in efforts to understand and treat these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a threefold preference for the hydrolysis of ATP over ADP.
See full target information ENTPD3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Life medicine 3:lnae036 PubMed39872439

2025

Integrated transcriptomic analysis reveals dysregulated immune infiltration and pro-inflammatory cytokines in the secretory endometrium of recurrent implantation failure patients.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Zhou,Dan Mo,Hanji Huang,Jiaqi Xu,Baoying Liao,Yinxue Wang,Di Mao,Zhonghong Zeng,Ziying Huang,Chao Zhang,Yihua Yang,Yang Yu,Heng Pan,Rong Li

Purinergic signalling 15:69-76 PubMed30637575

2019

Allergic sensitization increases the amount of extracellular ATP hydrolyzed by guinea pig leukocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jaime Chávez,Mario H Vargas,Jesús Martínez-Zúñiga,Ramcés Falfán-Valencia,Enrique Ambrocio-Ortiz,Verónica Carbajal,Rosa Sandoval-Roldán
View all publications
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