Anti-Eosinophil derived neurotoxin antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The eosinophil derived neurotoxin performs significant immune modulation roles. EDN modulates immune activity by acting as an attractant for dendritic cells and T-cells all important players in the immune system. Although not part of a larger protein complex EDN interacts with other immune molecules to propagate inflammatory reactions. Its involvement in antiviral activity also indicates EDN possesses the ability to participate in defense against viral infections enhancing immune responses in tissues where viral invasion occurs.

Pathways

Eosinophil derived neurotoxin plays essential roles in immune signaling and inflammatory pathways. In the immune signaling pathway EDN interacts with key proteins such as IL-5 and eotaxin which guide the recruitment and activation of eosinophils. Inflammatory pathways involving EDN include the promotion of inflammation through cytokine release and cell infiltration. Furthermore EDN is related to ribonuclease proteins through its ribonucleolytic activities linking it to enzymatic degradation pathways which impact RNA processing during immune responses.