AB179453

Anti-EPB41L1 antibody [EPR11090]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal EPB41L1 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 1 publication.

View Alternative Names

KIAA0338, EPB41L1, Band 4.1-like protein 1, Erythrocyte membrane protein band 4.1-like 1, Neuronal protein 4.1, 4.1N

3 Images

Supplier Data

Immunoprecipitation - Anti-EPB41L1 antibody [EPR11090] (AB179453)

Western blot analysis on immunoprecipitation pellet from Human fetal brain lysate immunoprecipitated using ab179453 at 1/10 dilution.

All lanes:

Immunoprecipitation - Anti-EPB41L1 antibody [EPR11090] (ab179453)

Predicted band size: 99 kDa

false

Flow Cytometry (Intracellular) - Anti-EPB41L1 antibody [EPR11090] (AB179453)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-EPB41L1 antibody [EPR11090] (AB179453)

Intracellular flow cytometric analysis of permeabilized Neuro 2a cellslabeling EPB41L1with ab179453 at 1/10 dilution (red),compared toa rabbit IgG negative control (green).

Supplier Data

Western blot - Anti-EPB41L1 antibody [EPR11090] (AB179453)

All lanes:

Western blot - Anti-EPB41L1 antibody [EPR11090] (ab179453) at 1/1000 dilution

Lane 1:

Human fetal brain tissue lysate at 10 µg

Lane 2:

Neuro 2a lysate at 10 µg

Predicted band size: 99 kDa

false

Carrier free

Anti-EPB41L1 antibody [EPR11090] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11090

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IP, WB, Flow Cyt (Intra)

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EPB41L1 gene encodes for protein 4.1N often referred to as EPB41L1 which is a member of the protein 4.1 superfamily. This protein has a molecular mass of approximately 145 kDa. EPB41L1 is expressed mostly in the nervous system including various brain regions and peripheral nerves. This protein is pivotal for maintaining structural integrity and stability of the cytoskeleton. EPB41L1 interacts with spectrin-actin complexes contributing to cellular shape and mechanical properties.

Biological function summary

Protein 4.1N plays a role in cellular processes like cell adhesion and migration. It participates in the formation of multiprotein complexes that include cytoskeletal elements and membrane proteins. This protein also influences neuronal function through its interaction with ion channels and synaptic proteins. EPB41L1 is integral to neuronal adaptability and contributes to synaptic plasticity processes impacting neuron communication.

Pathways

EPB41L1 is heavily involved in the signal transduction pathways within neurons. This protein associates with the Ras signaling pathway and can engage with proteins like Ras-related proteins that influence cell proliferation and differentiation. Additionally EPB41L1 is part of the integrin signaling pathway where it modulates cellular interactions with the extracellular matrix and impacts cell movement.

EPB41L1 has connections to neurodevelopmental and psychiatric disorders including schizophrenia and autism spectrum disorders. Impaired EPB41L1 function may disrupt neuronal communication leading to cognitive and behavioral symptoms. The protein is also linked to interactions with DISC1 a protein associated with psychiatric conditions providing insights into its role in the etiology of these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.

See full target information EPB41L1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 43:5469-5493 PubMed39333773

2024

The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Huang,Yao Wang,Xin Jia,Changfeng Zhao,Meiqi Zhang,Mi Bao,Pan Fu,Cuiqin Cheng,Ruona Shi,Xiaofei Zhang,Jun Cui,Gang Wan,Anlong Xu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-EPB41L1 antibody [EPR11090]

Immunoprecipitation - Anti-EPB41L1 antibody [EPR11090] (AB179453)

Flow Cytometry (Intracellular) - Anti-EPB41L1 antibody [EPR11090] (AB179453)

Western blot - Anti-EPB41L1 antibody [EPR11090] (AB179453)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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