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AB179809

Anti-EPB41L1 antibody [EPR11091]

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(1 Publication)

Rabbit Recombinant Monoclonal EPB41L1 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.

View Alternative Names

KIAA0338, EPB41L1, Band 4.1-like protein 1, Erythrocyte membrane protein band 4.1-like 1, Neuronal protein 4.1, 4.1N

3 Images
Flow Cytometry (Intracellular) - Anti-EPB41L1 antibody [EPR11091] (AB179809)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-EPB41L1 antibody [EPR11091] (AB179809)

Intracellular flow cytometrical analysis of permeabilized Neuro-2a cells labeling EPB41L1 with ab178909 at 1/10 (red) or a rabbit IgG (negative) (green).

Immunoprecipitation - Anti-EPB41L1 antibody [EPR11091] (AB179809)
  • IP

Unknown

Immunoprecipitation - Anti-EPB41L1 antibody [EPR11091] (AB179809)

Immunoprecipitation. ab178909 at 1/1000 for WB labeling EPB41L1 in Human fetal brain lysate immunoprecipitated using ab178909 at 1/10.

All lanes:

Immunoprecipitation - Anti-EPB41L1 antibody [EPR11091] (ab179809)

Predicted band size: 99 kDa

false

Western blot - Anti-EPB41L1 antibody [EPR11091] (AB179809)
  • WB

Supplier Data

Western blot - Anti-EPB41L1 antibody [EPR11091] (AB179809)

All lanes:

Western blot - Anti-EPB41L1 antibody [EPR11091] (ab179809) at 1/1000 dilution

All lanes:

Human fetal brain tissue lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 99 kDa

false

  • Carrier free

    Anti-EPB41L1 antibody [EPR11091] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11091

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

Flow Cyt (Intra), IP, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EPB41L1 gene encodes for protein 4.1N often referred to as EPB41L1 which is a member of the protein 4.1 superfamily. This protein has a molecular mass of approximately 145 kDa. EPB41L1 is expressed mostly in the nervous system including various brain regions and peripheral nerves. This protein is pivotal for maintaining structural integrity and stability of the cytoskeleton. EPB41L1 interacts with spectrin-actin complexes contributing to cellular shape and mechanical properties.
Biological function summary

Protein 4.1N plays a role in cellular processes like cell adhesion and migration. It participates in the formation of multiprotein complexes that include cytoskeletal elements and membrane proteins. This protein also influences neuronal function through its interaction with ion channels and synaptic proteins. EPB41L1 is integral to neuronal adaptability and contributes to synaptic plasticity processes impacting neuron communication.

Pathways

EPB41L1 is heavily involved in the signal transduction pathways within neurons. This protein associates with the Ras signaling pathway and can engage with proteins like Ras-related proteins that influence cell proliferation and differentiation. Additionally EPB41L1 is part of the integrin signaling pathway where it modulates cellular interactions with the extracellular matrix and impacts cell movement.

EPB41L1 has connections to neurodevelopmental and psychiatric disorders including schizophrenia and autism spectrum disorders. Impaired EPB41L1 function may disrupt neuronal communication leading to cognitive and behavioral symptoms. The protein is also linked to interactions with DISC1 a protein associated with psychiatric conditions providing insights into its role in the etiology of these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
See full target information EPB41L1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:111186 PubMed39524334

2024

Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Huang,Cantao Li,Wenjing Xu,Fenfen Li,Ying Hua,Changyu Xu,Chenxi Wu,Yihuan Wang,Xiaoxi Zhang,Daozong Xia
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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