Rabbit Polyclonal EPDR1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to EPDR1, fused to EPDR1.
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Publications
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- Aging cell 21:e137072022The lysosomal proteome of senescent cells contributes to the senescence secretome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMiguel Rovira,Rebecca Sereda,David Pladevall-Morera,Valentina Ramponi,Ines Marin,Mate Maus,Julio Madrigal-Matute,Antonio Díaz,Fernando García,Javier Muñoz,Ana María Cuervo,Manuel SerranoPubMed 36087066
- JBMR plus 5:e105312021CRISPR-Cas9-Mediated Genome Editing Confirms as an Effector Gene at the BMD GWAS-Implicated '' Locus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJames A Pippin,Alessandra Chesi,Yadav Wagley,Chun Su,Matthew C Pahl,Kenyaita M Hodge,Matthew E Johnson,Andrew D Wells,Kurt D Hankenson,Struan F A GrantPubMed 34532616
- Scientific reports 10:37232020EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness.Applications:Unspecified applicationReactive species:Unspecified reactive speciesF Gimeno-Valiente et. al.PubMed 32111877
- Nature communications 10:12602019Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlessandra Chesi,Yadav Wagley,Matthew E Johnson,Elisabetta Manduchi,Chun Su,Sumei Lu,Michelle E Leonard,Kenyaita M Hodge,James A Pippin,Kurt D Hankenson,Andrew D Wells,Struan F A GrantPubMed 30890710
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Fusion protein corresponding to EPDR1, fused to EPDR1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UM22
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500 - 1/2000 | Notes - |
Species Human | Dilution info 1/500 - 1/2000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/40 - 1/200 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Target data
Function
Binds anionic lipids and gangliosides at acidic pH.
Alternative names
MERP1, UCC1, EPDR1, Mammalian ependymin-related protein 1, MERP-1, Upregulated in colorectal cancer gene 1 protein
Recommended products
Rabbit Polyclonal EPDR1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to EPDR1, fused to EPDR1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Fusion protein corresponding to EPDR1, fused to EPDR1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UM22
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
EPDR1 also known as Ependymin-Related 1 is a protein involved in cellular adhesion and signaling. It has an approximate molecular mass of 55 kDa. EPDR1 is expressed in various tissues with significant levels found in the brain and also in some cancerous tissues. The protein plays a role in cellular interaction by mediating cell-cell and cell-matrix adhesion contributing to cellular cohesion and integrity.
- Biological function summary
EPDR1 functions in processes of cell adhesion and immune response modulation. It may form complexes with other proteins that help regulate the structural organization of cells within tissue matrices. This modulation is essential for the repair and maintenance of tissue architecture actively influencing how cells respond to environmental changes.
- Pathways
EPDR1 is significant in the ECM-receptor interaction pathway and plays a role in cell communication pathways. It interacts with other proteins like integrins which are important in mediating outside-in signaling processes. This interaction facilitates various downstream signaling events that are necessary for maintaining cell and tissue structure.
- Associated diseases and disorders
EPDR1 has been associated with cancer and neurodegenerative diseases. It may influence cancer progression through its impact on cell adhesion potentially affecting metastasis by altering cell motility and detachment. In neurological contexts the relationship with neurodegenerative diseases links to proteins like amyloid-beta where modulation by EPDR1 can affect disease progression by influencing cellular adhesion properties in neural tissues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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2 product images
Western blot - Anti-EPDR1 antibody - C-terminal (ab197932)
8% SDS-PAGE
All lanes: Western blot - Anti-EPDR1 antibody - C-terminal (ab197932) at 1/850 dilution
Lane 1: Mouse brain tissue lysate at 40 µg
Lane 2: Human fetal muscle tissue lysate at 40 µg
Developed using the ECL technique.
Predicted band size: 25 kDa
Exposure time: 20s
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPDR1 antibody - C-terminal (ab197932)
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling EPDR1 with ab197932 at 1/40 dilution.
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