Rabbit Polyclonal Eph antibody. Suitable for ELISA, WB and reacts with Drosophila melanogaster samples.
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
| ELISA | WB | |
|---|---|---|
| Drosophila melanogaster | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Drosophila melanogaster | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Drosophila melanogaster | Dilution info Use at an assay dependent concentration. | Notes - |
CG1511, CT3831, Dek7, Deph, Dmel\Eph, Drosophila eph, EK7, EPH, Eph kinase, Eph receptor, Eph receptor tyrosine kinase, Ephrin receptors, FBgn0015726, FBgn0023093, RPTK Dek7
Rabbit Polyclonal Eph antibody. Suitable for ELISA, WB and reacts with Drosophila melanogaster samples.
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
Eph receptors also known as EPH receptors or EPHA/EPHB are a group of receptor tyrosine kinases. Typically they are involved in cellular processes like cell adhesion shape and movement. Eph receptors play a role in the signaling dynamics between cells and tissues particularly through interactions with ephrin ligands. These receptors exhibit weights of around 100-125 kDa and are found in various tissues including the brain where they contribute to nervous system development and function.
Eph receptors influence cell positioning and boundary formation in the development of tissues and organs. They are a part of receptor-ligand complexes and engage in bidirectional signaling that impacts cellular dynamics. The Eph/ephrin interactions affect neural development angiogenesis and tissue patterning where they help define the spatial organization of cells and guide cell migration.
These receptors integrate into the Eph/ephrin signaling and axon guidance pathways. Within these pathways they interact with several molecules including Rac1 and RhoA which are important for cytoskeleton reorganization. Eph receptors also link to MAP kinase pathways influencing cellular proliferation differentiation and migration decisions. This establishes their role in determining cell fate and positioning during embryogenesis and wound healing.
Eph receptors have associations with cancer and neurological disorders. Dysregulation of Eph-ephrin signaling can contribute to tumorigenesis affecting tumor growth metastasis and angiogenesis. They also relate to Alzheimer's disease where aberrant Eph receptor signaling may disrupt cellular communication and synapse function. Interactions with proteins like ADAM10 and NMDA receptors further connect these pathways to disease pathogenesis making Eph receptors potential targets for therapeutic intervention.
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