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AB128224

Anti-Eph antibody

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(1 Publication)

Rabbit Polyclonal Eph antibody. Suitable for ELISA, WB and reacts with Drosophila melanogaster samples. Cited in 1 publication.

View Alternative Names

CG1511, CT3831, Dek7, Deph, Dmel\Eph, Drosophila eph, EK7, EPH, Eph kinase, Eph receptor, Eph receptor tyrosine kinase, Ephrin receptors, FBgn0015726, FBgn0023093, RPTK Dek7

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Drosophila melanogaster

Applications

ELISA, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Drosophila melanogaster": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Eph receptors also known as EPH receptors or EPHA/EPHB are a group of receptor tyrosine kinases. Typically they are involved in cellular processes like cell adhesion shape and movement. Eph receptors play a role in the signaling dynamics between cells and tissues particularly through interactions with ephrin ligands. These receptors exhibit weights of around 100-125 kDa and are found in various tissues including the brain where they contribute to nervous system development and function.
Biological function summary

Eph receptors influence cell positioning and boundary formation in the development of tissues and organs. They are a part of receptor-ligand complexes and engage in bidirectional signaling that impacts cellular dynamics. The Eph/ephrin interactions affect neural development angiogenesis and tissue patterning where they help define the spatial organization of cells and guide cell migration.

Pathways

These receptors integrate into the Eph/ephrin signaling and axon guidance pathways. Within these pathways they interact with several molecules including Rac1 and RhoA which are important for cytoskeleton reorganization. Eph receptors also link to MAP kinase pathways influencing cellular proliferation differentiation and migration decisions. This establishes their role in determining cell fate and positioning during embryogenesis and wound healing.

Eph receptors have associations with cancer and neurological disorders. Dysregulation of Eph-ephrin signaling can contribute to tumorigenesis affecting tumor growth metastasis and angiogenesis. They also relate to Alzheimer's disease where aberrant Eph receptor signaling may disrupt cellular communication and synapse function. Interactions with proteins like ADAM10 and NMDA receptors further connect these pathways to disease pathogenesis making Eph receptors potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Eph
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of experimental biology 220:1187-1191 PubMed28104798

2017

Central metabolic sensing remotely controls nutrient-sensitive endocrine response in via Sir2/Sirt1-upd2-IIS axis.

Applications

Unspecified application

Species

Unspecified reactive species

Kushal K Banerjee,Rujuta S Deshpande,Pranavi Koppula,Champakali Ayyub,Ullas Kolthur-Seetharam
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Product promise

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For full details, please see our Terms & Conditions

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