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AB217363

Anti-Eph receptor A1/EphA1 antibody

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(2 Publications)

Rabbit Polyclonal Eph receptor A1/EphA1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human EFNA1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

EPH, EPHT, EPHT1, EPHA1, Ephrin type-A receptor 1, hEpha1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eph receptor A1/EphA1 antibody (AB217363)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eph receptor A1/EphA1 antibody (AB217363)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung carcinoma tissue labeling Ephrin A1 with ab217363 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human EFNA1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P20827

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Eph receptor A1 also known by the alternative name EphA1 is a member of the ephrin receptor family part of the larger group of receptor tyrosine kinases. The EphA1 protein carries a molecular mass of approximately 108 kDa. Mechanically it functions as a cellular signaling molecule by binding ephrins its membrane-bound ligands which initiates bidirectional signaling pathways. This interaction typically occurs at cell-cell interfaces involving dynamic communication essential for cellular processes. EphA1 is expressed in a variety of tissues with a significant presence in epithelial tissues where it plays roles in maintaining tissue architecture.
Biological function summary

EphA1 contributes to cellular adhesion migration and positioning linking to ephrin ligands to form signaling complexes. These complexes aid in regulating developmental processes such as angiogenesis and neuronal development by transmitting signals that control cell shape and movement. The EphA1 receptor also influences cell proliferation and plays a role in the inhibition of cell migration by responding to concentration gradients of ephrin ligands. Its ability to control cellular boundaries and morphology highlights its importance in tissue patterning and organogenesis.

Pathways

EphA1 integrates into the Eph/ephrin signaling pathway a critical framework for developmental processes and cellular organization. This pathway involves cross-talk with the MAPK signaling cascade which further influences cell proliferation and differentiation. The interplay between EphA1 and other Eph receptors like EphB2 enhances bidirectional signaling that accommodates both forward and reverse signal transduction a feature that accommodates dynamic cellular responses in development and homeostasis.

EphA1 has significant connections to cancer progression and metastasis particularly in colorectal carcinoma and melanoma. Alterations in EphA1 expression can lead to deregulated cellular pathways contributing to tumor development and spread. EphA1's relationship with proteins like ephrin A1 and other Eph receptors such as EphA2 provides a link between its dysregulation and cancer pathology highlighting its potential as a therapeutic target in oncology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
See full target information EPHA1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular neurobiology 58:913-925 PubMed33057926

2020

EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjun Ma,Zhidong Wang,Siyuan Chen,Wenhua Sun,Qi Gu,Dongsheng Li,Jinhua Zheng,Hongqi Yang,Xue Li

Oncology letters 19:442-448 PubMed31897157

2020

Influence of demethylation on regulatory T and Th17 cells in myelodysplastic syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyan Jia,Wenzhong Yang,Xiaohui Zhou,Lu Han,Jumei Shi
View all publications
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