Anti-Eph receptor A2+A3+A4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Eph receptor A2 A3 and A4 collectively known as the Ephrin type-A receptor group are part of the larger Eph receptor family which is critical in cellular communication mechanisms. These receptors are transmembrane proteins with a molecular weight of approximately 110 to 130 kDa and they are expressed widely throughout tissues such as the brain heart and lungs. These receptors are involved in bidirectional signaling; they interact with ephrin-A ligands to mediate cell-cell contact through forward and reverse signaling pathways.

Biological function summary

These Eph receptors play an essential role in the regulation of cell movement and organization particularly in the nervous system. This receptor group works by forming a receptor-ligand complex with ephrin-A proteins which is important for guiding cell positioning and tissue patterning during development. These interactions regulate axon guidance angiogenesis and the formation of neural networks influencing how cells sort and migrate.

Pathways

Eph receptor A2 A3 and A4 function as key players in the Rho GTPase signaling and MAPK/ERK pathways. These pathways regulate several processes such as cell proliferation differentiation and migration. The Eph receptor family interacts with other proteins like RhoA and Erk1/2 which are critical for modulating cytoskeletal dynamics and activating downstream effects within these pathways impacting cellular structure and signaling.

Associated diseases and disorders

These Eph receptors are associated with various conditions including cancer and neurodevelopmental disorders. Abnormal expression or mutations in EphA2 for instance have connections to breast cancer where it communicates with proteins like STAT3 to influence tumor growth and progression. In neurodevelopmental disorders altered signaling involving Eph receptors can impact interactions with key proteins like NRG1 leading to abnormal brain structure formation and behavioral outcomes. Understanding these pathways and interactions provides insight into potential therapeutic targets.