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AB136116

Anti-Eph receptor A5/BSK antibody

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(1 Publication)

Rabbit Polyclonal Eph receptor A5/BSK antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

BSK, EHK1, HEK7, TYRO4, EPHA5, Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EPH-like kinase 7, EHK-1, EK7, hEK7

1 Images
Western blot - Anti-Eph receptor A5/BSK antibody (AB136116)
  • WB

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Western blot - Anti-Eph receptor A5/BSK antibody (AB136116)

All lanes:

Western blot - Anti-Eph receptor A5/BSK antibody (ab136116) at 1/500 dilution

All lanes:

HeLa cell lysate at 30 µg

Predicted band size: 115 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab136116 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Eph receptor A5 also known as BSK is a member of the Eph family of receptor tyrosine kinases. It exhibits a molecular mass of approximately 116 kDa. This receptor is fundamentally involved in mediating cell adhesion and migration playing an essential role in cellular communication. Eph receptor A5/BSK is predominantly expressed in tissues of the nervous system including the brain and spinal cord which indicates an intrinsic role in neurodevelopment and synaptic organization.
Biological function summary

Eph receptor A5 engages in bidirectional signaling with its corresponding ephrin ligands creating a dynamic interaction network important for neuronal pathfinding and neurogenesis. This receptor acts as part of a larger complex self-associating with other family members to modulate cell position and boundary formation in development. The receptor's activity critically contributes to the regulation of axon guidance during neural development ensuring correct neuronal connections.

Pathways

Eph receptor A5 involves itself in the RhoA signaling pathway affecting cytoskeletal dynamics. It works alongside other Eph receptors and related proteins such as ephrin-A5 and Rho GTPases to manage cellular movement and growth cone stability. This receptor also integrates into the PI3K/AKT pathway influencing cell survival and proliferation where it potentially interfaces with insulin receptor substrates.

Eph receptor A5 shows connections to conditions like glioblastoma and Alzheimer's disease. In glioblastoma the aberrant signaling of Eph receptor A5 contributes to tumor progression and cell invasion interacting with proteins like EphA2. In Alzheimer's disease altered expression of this receptor affects synaptic function potentially leading to cognitive decline and it shares pathways with related proteins like beta-amyloid precursor protein.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
See full target information EPHA5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of natural products 83:3080-3092 PubMed33021790

2020

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Corena V Grant,Shengxin Cai,April L Risinger,Huiyun Liang,Barry R O'Keefe,John G Doench,Robert H Cichewicz,Susan L Mooberry
View all publications
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