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AB113239

Anti-Eph receptor A6 antibody

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(1 Publication)

Rabbit Polyclonal Eph receptor A6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EPHA6 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

EHK2, HEK12, EPHA6, Ephrin type-A receptor 6, EPH homology kinase 2, EPH-like kinase 12, EHK-2, EK12

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eph receptor A6 antibody (AB113239)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eph receptor A6 antibody (AB113239)

ab113239, at 10 µg/ml, staining Eph receptor A6 in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eph receptor A6 antibody (AB113239)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eph receptor A6 antibody (AB113239)

ab113239, at 10 µg/ml, staining Eph receptor A6 in Formalin-fixed, Paraffin-embedded Human Brain cerebellum tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-Eph receptor A6 antibody (AB113239)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Eph receptor A6 antibody (AB113239)

ab113239, at 1/100 dilution, staining Eph receptor A6 in COS7 cells by Immunofluorescence. The image on the right has been treated with the synthesized peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, African green monkey

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human EPHA6 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9UF33

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Eph receptor A6 also known as EphA6 acts as a receptor tyrosine kinase which belongs to the ephrin receptor subfamily. Its structure involves a mass of approximately 110 kDa. EphA6 is expressed in various tissues with notably high expression in the brain. It plays a mechanical role by binding ephrin ligands which leads to receptor activation and downstream signaling.
Biological function summary

Ephrin-Eph receptor interactions regulate processes like cell adhesion migration and development with EphA6 influencing neural development and plasticity. It does not form a complex on its own but interacts with ephrin ligands to initiate cellular responses. These functions are important for maintaining cellular architecture and communication during development.

Pathways

EphA6 participates in the Ephrin signaling pathway engaging in complex interactions to mediate developmental processes. This receptor also involves itself in the neural development pathway. Proteins like EphA2 and ephrin-A1 frequently interact with EphA6 within these pathways facilitating various signaling cascades that are significant for cellular architecture.

Abnormal expression or function of EphA6 has been associated with neurodegenerative disorders like Alzheimer's disease. Changes in EphA6 participate in disruption of synaptic connections. Within cancer biology EphA6 has been implicated in tumor progression and metastasis. In these contexts it may interact with other proteins such as EGFR influencing cellular behaviors related to malignancy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
See full target information EPHA6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40332055

2025

A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Yunxi Zhang,Lilie Gailloud,Alexander Shin,Jessica Fewkes,Rosella Pinckney,Andrew Whiting,Paul Chazot
View all publications
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Product promise

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