Anti-Eph receptor B6 antibody [RM0057-9B17]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

EphB6 plays an important role in cell adhesion migration and regulation of immune responses. Although it forms part of the larger Eph-ephrin signaling complex EphB6 contributes to cellular communication without exhibiting intrinsic catalytic action. Its interactions often influence cytoskeletal organization and can impact cell shape and movement. More specifically EphB6 signaling is modulated through its ability to form complexes with other kinases such as EphB1 or EphB4 which can provide the kinase activity needed for downstream effects.

Pathways

EphB6 participates in important signaling networks such as the PI3K/AKT and MAPK pathways. These pathways are important for regulating cell survival and proliferation. In the context of these pathways EphB6 interacts with proteins such as PI3K influencing pathway activation and cellular outcomes. Eph-ephrin complexes can also integrate into the MAPK pathway through other Eph receptors facilitating various cellular responses in development and immune function.