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AB106437

Anti-EPHA10 antibody

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(2 Publications)

Rabbit Polyclonal EPHA10 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Ephrin type-A receptor 10.

View Alternative Names

Ephrin type-A receptor 10, EPHA10

1 Images
Western blot - Anti-EPHA10 antibody (AB106437)
  • WB

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Western blot - Anti-EPHA10 antibody (AB106437)

Lane 1:

Western blot - Anti-EPHA10 antibody (ab106437) at 1 µg/mL

Lane 2:

Western blot - Anti-EPHA10 antibody (ab106437) at 2 µg/mL

All lanes:

293 cell lysate at 15 µg

Predicted band size: 109 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Ephrin type-A receptor 10. The exact immunogen used to generate this antibody is proprietary information.

Q5JZY3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EPHA10 also known as Ephrin type-A receptor 10 is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. It has a molecular mass of approximately 110 kDa. EPHA10 functions through binding with ephrin ligands A1 through A5 facilitating cell-cell communication. Expression of EPHA10 occurs mainly in the human testes and breasts suggesting a role in reproductive and lactation-related processes.
Biological function summary

EPHA10 participates in the modulation of cellular architecture and tissue patterning. Its role is to mediate cell adhesion and shape during developmental processes. Although not explicitly part of a large complex EPHA10 interacts closely with other ephrins and receptors to induce cellular signaling cascades necessary for its functions. These signaling interactions play important roles in regulating developmental biology and tissue specificity.

Pathways

EPHA10 engages in axon guidance and synaptic plasticity pathways influencing neuron positioning and connectivity. It interacts with related proteins such as EPHA2 and ephrin-A family members acting as important signaling intermediaries. These pathways maintain neural network architecture and facilitate adaptive synaptic responses during learning and memory.

Research indicates connections between EPHA10 dysregulation and cancer notably breast cancer where altered expression can drive tumorigenic processes. It also associates with reproductive health issues due to its expression in testes and potential influence in sperm maturation. EPHA10's altered signaling interfaces with the roles of proteins like EPHA2 in oncogenesis enhancing cellular transformation and invasion processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
See full target information Ephrin type-A receptor 10
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 69:1215-1221 PubMed33990369

2021

Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Peng,Danhua Zhang

Drug delivery 25:723-737 PubMed29513049

2018

Eph A10-modified pH-sensitive liposomes loaded with novel triphenylphosphine-docetaxel conjugate possess hierarchical targetability and sufficient antitumor effect both in vitro and in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Jiulong Zhang,Chunrong Yang,Shuang Pan,Menghao Shi,Jie Li,Haiyang Hu,Mingxi Qiao,Dawei Chen,Xiuli Zhao
View all publications
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