AB64814

Anti-Ephrin A3 antibody

(4 Reviews)

(5 Publications)

Rabbit Polyclonal Ephrin A3 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human EFNA3.

View Alternative Names

EFL2, EPLG3, LERK3, EFNA3, Ephrin-A3, EFL-2, EHK1 ligand, EPH-related receptor tyrosine kinase ligand 3, EHK1-L, LERK-3

1 Images

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Western blot - Anti-Ephrin A3 antibody (AB64814)

All lanes:

Western blot - Anti-Ephrin A3 antibody (ab64814) at 1/500 dilution

Lane 1:

Extracts from HepG2 cells at 5 µg

Lane 2:

Extracts from Jurkat cells at 5 µg

Lane 3:

Extracts from Jurkat cells at 5 µg with immunising peptide

Predicted band size: 26 kDa

Observed band size: 38 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human EFNA3. The exact immunogen used to generate this antibody is proprietary information.

P52797

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab64814 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ephrin A3 also known as Ephrin-A3 or EFNA3 is a member of the ephrin family that interacts with Eph receptors which are a group of tyrosine kinase receptors. Ephrin A3 has a mass of approximately 24 kDa. It is expressed in various tissues including the brain where it plays a significant role in neural development. The expression pattern of Ephrin A3 suggests its involvement in a wide range of physiological processes.

Biological function summary

Ephrin A3 acts as an important regulator in cell communication and spatial organization within the brain's neuronal network. It forms a complex with Eph receptors on adjacent cells leading to bidirectional signaling necessary for processes like axon guidance and synaptic plasticity. Ephrin A3's ability to guide axons is important for neural pathfinding during development. It also participates in the clustering of neurons required for the formation of precise neural circuits.

Pathways

Ephrin A3 is a significant player in the Eph/ephrin signaling pathway which influences the dynamics of cell adhesion shape and movement. It is closely related to EphA3 and EphA4 receptors through these pathways. The signaling influences the cytoskeleton affecting cell migration and tissue boundary formation. Additionally Ephrin A3 interacts within the Rho family of GTPase signaling pathways that regulate cytoskeletal rearrangements impacting cellular morphology and motility.

Ephrin A3 is implicated in conditions like cancer and neurological disorders. Aberrant expression or signaling of Ephrin A3 contributes to tumor progression and metastasis potentially through its role in modifying cell adhesion and migration. Through its involvement in the neural network it may also relate to neurodegenerative diseases. The interaction with proteins like EphA2 in cancer highlights its potential as a therapeutic target. Understanding these interactions opens pathways for strategies to modulate its function in disease contexts.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

See full target information EFNA3

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Biochemistry and biophysics reports 43:102132 PubMed40688500

2025

Exploring LAT-derived miRNAs as regulatory agents of EphrinA3 in glioblastoma multiforme.

Applications

Unspecified application

Species

Unspecified reactive species

Fatemeh Saadatpour,Ehsan Arefian

Endocrinology and metabolism (Seoul, Korea) 37:290-302 PubMed35390249

2022

Developmental Hypothyroidism Influences the Development of the Entorhinal-Dentate Gyrus Pathway of Rat Offspring.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Jin,Ranran Wang,Shiqiao Peng,Xin Liu,Hanyi Zhang,Xue He,Weiping Teng,Xiaochun Teng

Bioengineered 13:8994-9005 PubMed35345980

2022

LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Jiang,Kankan Yang,Chao Tang,Rui Chen,Chao Wang

ASN neuro 13:17590914211044359 PubMed34618621

2021

Role of EphrinA3 in HIV-1 Neuropathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Chitra Mohinder Singh Singal,Paritosh Jaiswal,Anuradha Mehta,Kanza Saleem,Pankaj Seth

The International journal of developmental biology 64:423-432 PubMed33063836

2020

Control of fibrosis by TGFβ signalling modulation promotes redifferentiation during limited regeneration of mouse ear.

Applications

Unspecified application

Species

Unspecified reactive species

RenéFernando Abarca-Buis,María Elena Contreras-Figueroa,David Garciadiego-Cázares,Edgar Krötzsch

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Ephrin A3 antibody

Western blot - Anti-Ephrin A3 antibody (AB64814)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise