Anti-Ephrin A4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ephrin A4 also known as EFNA4 is part of the ephrin family of proteins. It interacts with Eph receptors and primarily functions as a ligand—a molecule that binds to another to form a complex—within this signaling system. Ephrin A4 is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage and its molecular mass is approximately 21 kDa. The expression of Ephrin A4 can be found in various tissues including the brain lungs and kidneys indicating its diverse roles in bodily functions.

Biological function summary

Ephrin A4 plays significant roles in the development and function of the nervous system. It works within the ephrin/Eph receptor signaling system impacting processes such as cell positioning and tissue boundary formation. Ephrin A4 is not an isolated component; it acts as part of a complex with Eph receptors influencing cell adhesion and shape. These interactions guide the cellular processes required for proper embryonic development.

Pathways

Ephrin A4 is involved in the ephrin signaling pathway and the MAPK/ERK pathway. These pathways regulate cell proliferation differentiation and migration which are essential for developmental processes. Ephrin A4 interacts with EphA receptors influencing these signaling cascades. This connection shows its significant influence on various cellular processes including those relevant in neural patterning.

Associated diseases and disorders

Ephrin A4 has associations with certain cancers and neurodegenerative illnesses. In cancer particularly breast cancer Ephrin A4 dysregulation links to uncontrolled cell proliferation and migration often in connection with EphA2 receptor overexpression. Furthermore in neurodegenerative conditions like Alzheimer's disease altered ephrin signaling involves the degradation of neural structures implicating interactions with EphB2. These associations underline the importance of Ephrin A4 in maintaining cellular and tissue health.