Anti-Ephrin B3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ephrin B3 also known as EFNB3 is a critical membrane-bound ligand for the Eph receptor tyrosine kinases. EFNB3 belongs to the ephrin family with a molecular mass of approximately 37 kDa. It predominantly expresses in the brain although researchers have detected it in other tissues as well. The protein plays a significant role in various cellular processes such as cell adhesion shape and migration.

Biological function summary

EFNB3 influences axon guidance and neural development. As part of a receptor-ligand complex it interacts with Eph receptors to regulate synaptic plasticity which is essential for learning and memory. This interaction also plays a role in mediating repulsive and attractive signals that guide neurons during developmental processes. EFNB3 exhibits distinct binding characteristics which determine specific cellular responses.

Pathways

EFNB3 influences both the ephrin signaling pathway and the nervous system development pathway. It engages with Eph receptors particularly EphB3 and EphA4 to trigger downstream signaling cascades that influence cellular structure and fate. The Eph-ephrin pathways are important in neurodevelopmental processes assisting in the formation of spatially regulated cell organization.

Associated diseases and disorders

EFNB3 has connections to neurodegenerative diseases and cancer. Abnormal EFNB3 signaling can contribute to Alzheimer's Disease due to its role in neuronal connectivity and communication. The protein also associates with glioblastoma as it can influence tumor cell invasiveness and growth. Changes in ephrin signaling can alter normal cellular behavior which may progress to various pathological conditions.