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AB115284

Anti-EPHX2 antibody

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(1 Publication)

Rabbit Polyclonal EPHX2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EPHX2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Bifunctional epoxide hydrolase 2, EPHX2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPHX2 antibody (AB115284)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPHX2 antibody (AB115284)

Human kidney formalin-fixed, paraffin-embedded tissue stained with ab115284 at 20 μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human EPHX2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P34913

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EPHX2 also known as soluble epoxide hydrolase is an enzyme that plays a mechanical role in the metabolism of epoxides to diols. The enzyme has a molecular mass of approximately 62 kDa. Scientists find EPHX2 primarily in the liver but it also expresses in other tissues such as the heart kidney and vasculature. Its diverse expression across different organs suggests its involvement in various physiological functions.
Biological function summary

Soluble epoxide hydrolase regulates the hydrolysis of epoxides which affects signaling molecules involved in inflammation and vascular tone. EPHX2 does not directly form a complex but functions within cellular environments to modulate lipid signaling pathways. Through its enzymatic action it converts epoxyeicosatrienoic acids (EETs) which helps to control vasodilation and anti-inflammatory responses.

Pathways

The enzyme soluble epoxide hydrolase integrates into the arachidonic acid metabolism pathway and the cytochrome P450 signaling pathway. In these pathways it interacts with metabolites like EETs influencing lipid signaling and inflammatory processes. Additionally its activity relates to proteins such as cyclooxygenase and lipoxygenase which participate in lipid mediator biosynthesis.

EPHX2 has links to cardiovascular diseases and chronic inflammation conditions. Altered EPHX2 activity may contribute to dysregulated blood pressure a factor in hypertension. Moreover the enzyme associates with other proteins like angiotensin-converting enzyme (ACE) which also plays a role in cardiovascular homeostasis. This relationship underlines the potential therapeutic importance of targeting EPHX2 in disease management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Bifunctional enzyme (PubMed : 12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed : 12574510, PubMed : 12869654, PubMed : 22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed : 12574510, PubMed : 12869654, PubMed : 21217101, PubMed : 22798687).. Bifunctional enzyme (PubMed : 12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed : 12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed : 22217705, PubMed : 22387545).
See full target information EPHX2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular physiology 239:212-226 PubMed38149479

2023

Cadherin-5 facilitated the differentiation of human induced pluripotent stem cells into sinoatrial node-like pacemaker cells by regulating β-catenin.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,Fengyuan Wang,Lin Yin,Yanhong Tang,Xi Wang,Congxin Huang
View all publications
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Product promise

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