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AB219978

Anti-Epigen antibody

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(1 Publication)

Rabbit Polyclonal Epigen antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EPGN aa 1-150.

View Alternative Names

UNQ3072/PRO9904, EPGN, Epigen, Epithelial mitogen, EPG

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Epigen antibody (AB219978)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Epigen antibody (AB219978)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-251 MG cells labeling Epigen with ab219978 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human EPGN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q6UW88

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Epigen protein also referred to by its gene name EPGN is a member of the epidermal growth factor (EGF) family. This protein has a molecular mass of approximately 19 kDa and is known for being expressed in several tissues with notable expression in the liver and heart. Its structure includes a single EGF-like domain that plays a role in its functional interaction with other cellular components.
Biological function summary

Epigen is involved in promoting cell proliferation and differentiation. It interacts with the epidermal growth factor receptor (EGFR) triggering downstream signaling pathways that influence cell growth. While Epigen acts independently it may have interactions that suggest participation in broader molecular complexes. These interactions contribute to its role in various physiological processes such as tissue repair and maintenance.

Pathways

Epigen engages in the EGFR signaling pathway an essential mechanism for regulating cell division and survival. This pathway includes proteins such as EGFR and its downstream effectors like the MAPK and PI3K pathways. Through these pathways Epigen influences cellular responses to growth signals effectively linking extracellular cues to intracellular actions.

Epigen is associated with cancer and cardiovascular diseases. Abnormal expression or activity of Epigen can lead to enhanced cell proliferation a hallmark of oncogenesis. Its interaction with proteins like EGFR has been implicated in tumor progression and metastasis. In cardiovascular conditions Epigen’s regulatory role on cardiac cells ties it to disorders where cell proliferation is disrupted or improperly controlled.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.
See full target information EPGN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Medical molecular morphology 57:200-217 PubMed38960952

2024

Histopathological growth pattern and vessel co-option in intrahepatic cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zihan Li,Hiep Nguyen Canh,Kenta Takahashi,Dong Le Thanh,Quynh Nguyen Thi,Rui Yang,Kaori Yoshimura,Yasunori Sato,Khuyen Nguyen Thi,Hiroki Nakata,Hiroko Ikeda,Kazuto Kozaka,Satoshi Kobayashi,Shintaro Yagi,Kenichi Harada
View all publications
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Product promise

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